病毒性心肌炎患者治疗前后血清IL-35水平的变化及其意义

发布时间：2018-09-18 11:30

【摘要】：目的观察病毒性心肌炎患者治疗前后血清白细胞介素35(IL-35)水平的变化,探讨其在病毒性心肌炎中的临床意义。方法选取2012年1月-2015年12月在该院心内科住院的病毒性心肌炎患者54例,以及健康体检者54例作为研究对象,将其分为观察组和对照组,测定血清IL-35、心肌肌钙蛋白Ⅰ(cTnI)、肌酸激酶同工酶(CK-MB)、白细胞介素17(IL-17)水平。结果 54例患者总有效率为94.4%。治疗前观察组IL-35([189.34±25.46)ng/L]与对照组([398.35±24.27)ng/L]比较,差异有统计学意义(P0.05),观察组cTnI、CK-MB和IL-17水平([0.45±0.04)μg/L、(34.53±4.37)u/L和(546.57±24.34)pg/ml]与对照组([0.03±0.01)μg/L、(8.57±1.26)u/L和(183.34±13.26)pg/ml]比较,差异有统计学意义(P0.05)。观察组治疗后IL-35水平([366.35±22.43)ng/L]与治疗前([189.34±25.46)ng/L]比较,差异有统计学意义(P0.05),治疗后cTnI、CK-MB和IL-17水平([0.07±0.02)μg/L、(11.35±1.65)u/L和(276.48±17.46)pg/ml]与治疗前([0.45±0.04)μg/L、(34.53±4.37)u/L和(546.57±24.35)pg/ml]比较,差异有统计学意义(P0.05)。治疗前后,男性和女性患者血清IL-35水平比较,差异无统计学意义(P0.05)。病毒性心肌炎患者血清IL-35水平与cTnI、CK-MB、IL-17呈负相关(P0.05)。结论病毒性心肌炎患者血清IL-35水平下降,经治疗后血清IL-35水平升高,IL-35可能参与病毒性心肌炎的发生、发展过程。
[Abstract]:Objective To observe the changes of serum interleukin-35 (IL-35) levels in patients with viral myocarditis before and after treatment and explore its clinical significance in viral myocarditis. The serum levels of IL-35, cTnI, CK-MB and IL-17 were measured in the two groups. Results The total effective rate was 94.4%. Before treatment, the serum levels of IL-35 ([189.34+25.46) ng/L) in the observation group were significantly higher than those in the control group ([398.35+24.27) ng/L). (P 0.05) The levels of cTnI, CK-MB and IL-17 in the observation group were significantly higher than those in the control group (P 0.05). The levels of IL-17 ([0.45+0.04)ug/L, (34.53+4.37)u/L and (546.57+24.34)pg/ml) were significantly higher than those of the control group ([0.03+0.01)ug/L, (8.57+1.26)u/L and (183.34+13.26)pg/ml), (P 0.05). After treatment, the levels of IL-35 ([366.35+22.43)ng/L] in the observation group were significantly higher than those of the control group ([189.34+25.46)] (P 0.05). After treatment, the levels of cTnI, CK-MB and IL-17 ([0.07+0.02)ug/L, (11.35+1.65)u/L and (276.48+17.46)pg/ml) were significantly different from those before treatment ([0.45+0.04)ug/L, (34.53+4.37)u/L and (546.57+24.35) pg/ml). There was no significant difference in the levels of serum IL-35 between male and female patients before and after treatment (P 0.05). The serum levels of IL-35 were negatively correlated with cTnI, CK-MB and IL-17 in patients with viral myocarditis (P 0.05).
【作者单位】：河南省新乡市中心医院心内一科;新乡医学院第三附属医院心内科;
【分类号】：R542.21

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