高血压不同级别与血清胆红素、血管内皮舒张功能的研究
发布时间：2018-09-18 13:56
【摘要】：目的:探讨血压的不同级别与间接胆红素(IBIL)、直接胆红素(DBIL)、总胆红素(TBIL)、血管内皮舒张功能(FMD)的关系。方法:根据入选与排除标准选,选取青海大学附属医院心内科1级高血压患者32例,2级高血压患者40例,3级高血压患者36例,另选取健康体检者34例为对照组。所有入选的高血压患者及健康体检者,均由我院检验科次日抽取晨静脉血5ml,离心后检测三种血清胆红素的水平。所有入选的患者及健康体检者,均由我院超声科专业技师,参照专业的方法,测量肱动脉血流介导的血管内皮舒张功能(FMD)。比较不同血压级别间的血清胆红素及FMD水平、血清胆红素与FMD之间的相关性。结果:健康对照组DBIL水平高于1级高血压DBIL水平(P0.05),提示差异无统计学意义。1级高血压DBIL水平高于2级高血压DBIL水平,高于3级高血压DBIL,且P0.05。健康对照组IBIL水平高于1级高血压水平,高于2级高血压水平,高于3级高血压水平,且P0.05。健康对照组TBIL水平高于1级高血压水平,高于2级高血压水平,高于3级高血压水平,且P0.05。健康对照组FMD水平,高于1级高血压水平,高于2级高血压水平,高于3级高血压水平,且P0.05。FMD与血IBIL、DBIL、TBIL呈正相关(r=0.433,P0.05;r=0.218,P0.05;r=0.446,p0.05)。结论:与健康对照组相比,高血压患者IBIL、TBIL水平均降低。随着高血压级别的升高,IBIL、DBIL、TBIL水平逐渐下降。健康对照组FMD水平高于高血压组,且随血压级别的升高逐渐降低。高血压患者FMD水平越低,IBIL、DBIL、TBIL水平越低。
[Abstract]:Aim: to investigate the relationship between blood pressure and indirect bilirubin (IBIL), direct bilirubin (DBIL), total bilirubin (TBIL), endothelium diastolic function (FMD). Methods: according to the criteria of selection and exclusion, 32 patients with grade 1 hypertension in the Department of Cardiology, affiliated Hospital of Qinghai University, 40 patients with grade 2 hypertension and 36 patients with grade 3 hypertension were selected as control group. All the selected hypertensive patients and healthy persons were collected from the morning venous blood of our hospital the next day and the serum bilirubin levels were measured after centrifugation. All the selected patients and healthy persons were examined by the ultrasound technicians in our hospital. The vascular endothelial diastolic function (FMD).) mediated by brachial artery blood flow was measured according to the professional methods. The levels of serum bilirubin and FMD, and the correlation between serum bilirubin and FMD were compared among different blood pressure levels. Results: the level of DBIL in healthy control group was higher than that in grade 1 hypertension (P0.05), suggesting that the level of DBIL in grade 1 hypertension was higher than that in grade 2 hypertension (P0.05), but the level of DBIL, in grade 3 hypertension was higher than that in grade 3 hypertension (P0.05). The level of IBIL in healthy control group was higher than that of grade 1 hypertension, higher than that of grade 2 hypertension and higher than that of grade 3 hypertension (P0.05). The level of TBIL in healthy control group was higher than that of grade 1 hypertension, higher than that of grade 2 hypertension and higher than that of grade 3 hypertension (P0.05). In the healthy control group, the level of FMD was higher than that of grade 1 hypertension, higher than that of grade 2 hypertension, and higher than that of grade 3 hypertension. There was a positive correlation between P0.05.FMD and serum IBIL,DBIL,TBIL. Conclusion: compared with the healthy control group, the level of IBIL,TBIL in hypertensive patients decreased. With the increase of hypertension grade, the level of TBIL decreased gradually. The level of FMD in healthy control group was higher than that in hypertension group, and decreased gradually with the increase of blood pressure level. The lower the level of FMD in hypertensive patients is, the lower the level of FMD is.
【学位授予单位】：青海大学
【学位级别】：硕士
【学位授予年份】：2017
【分类号】：R544.1
本文编号：2248129
[Abstract]:Aim: to investigate the relationship between blood pressure and indirect bilirubin (IBIL), direct bilirubin (DBIL), total bilirubin (TBIL), endothelium diastolic function (FMD). Methods: according to the criteria of selection and exclusion, 32 patients with grade 1 hypertension in the Department of Cardiology, affiliated Hospital of Qinghai University, 40 patients with grade 2 hypertension and 36 patients with grade 3 hypertension were selected as control group. All the selected hypertensive patients and healthy persons were collected from the morning venous blood of our hospital the next day and the serum bilirubin levels were measured after centrifugation. All the selected patients and healthy persons were examined by the ultrasound technicians in our hospital. The vascular endothelial diastolic function (FMD).) mediated by brachial artery blood flow was measured according to the professional methods. The levels of serum bilirubin and FMD, and the correlation between serum bilirubin and FMD were compared among different blood pressure levels. Results: the level of DBIL in healthy control group was higher than that in grade 1 hypertension (P0.05), suggesting that the level of DBIL in grade 1 hypertension was higher than that in grade 2 hypertension (P0.05), but the level of DBIL, in grade 3 hypertension was higher than that in grade 3 hypertension (P0.05). The level of IBIL in healthy control group was higher than that of grade 1 hypertension, higher than that of grade 2 hypertension and higher than that of grade 3 hypertension (P0.05). The level of TBIL in healthy control group was higher than that of grade 1 hypertension, higher than that of grade 2 hypertension and higher than that of grade 3 hypertension (P0.05). In the healthy control group, the level of FMD was higher than that of grade 1 hypertension, higher than that of grade 2 hypertension, and higher than that of grade 3 hypertension. There was a positive correlation between P0.05.FMD and serum IBIL,DBIL,TBIL. Conclusion: compared with the healthy control group, the level of IBIL,TBIL in hypertensive patients decreased. With the increase of hypertension grade, the level of TBIL decreased gradually. The level of FMD in healthy control group was higher than that in hypertension group, and decreased gradually with the increase of blood pressure level. The lower the level of FMD in hypertensive patients is, the lower the level of FMD is.
【学位授予单位】：青海大学
【学位级别】：硕士
【学位授予年份】：2017
【分类号】：R544.1
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1 张璐;高血压不同级别与血清胆红素、血管内皮舒张功能的研究[D];青海大学;2017年
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