老年冠心病患者应用他汀类药物的临床疗效及安全性观察

发布时间：2018-10-13 09:22

【摘要】：背景冠心病是中老年人群常见的一种心血管疾病。冠心病发作时可引起心绞痛、心律失常、心力衰竭等症状,患者如果不接受有效的治疗,可能发生猝死等危险事件。随着我国进入老龄化时代,冠心病的患病人数持续增多,已经成为危害我国中老年人群生命安全的首要因素,他汀类药物是目前临床医学界治疗老年冠心病患者的首选药物。目的本文研究的目的是探讨不同类型的他汀类药物治疗老年冠心病的临床疗效及安全性,旨在为临床医生使用他汀类药物治疗老年冠心病提供临床参考。资料与方法本研究选取老年冠心病患者300例,随机分为两组,每组各150例。分别采用洛伐他汀和阿托伐他汀治疗三个月的后,比较两组患者的药物治疗效果及用药安全性。结果使用他汀类药物治疗老年冠心病患者时,能有效降低患者血液中的总胆固醇含量(mmol/L)、空腹血糖含量(mmol/L)、c敏反应蛋白(mg/L)和低密度脂蛋白(mg/L)指标;产生的用药不良反应较低,是一种安全有效的治疗方式。结论总之,临床上在治疗老年冠心病人时,可以应用不同种类的他汀类药物给予对症治疗。不同种类的他汀类药物都能在短时间内降低患者血脂,改善患者心血管功能,降低冠心病的发作概率,值得在老年冠心病人中推广使用。
[Abstract]:Background Coronary heart disease is a common cardiovascular disease in the elderly. Coronary heart disease can cause angina pectoris, arrhythmia, heart failure and other symptoms, if patients do not receive effective treatment, may occur sudden death and other dangerous events. With the aging of our country, the number of patients with coronary heart disease (CHD) has been increasing, which has become the primary factor that endangers the life of the middle-aged and elderly people in China. Statins are the first choice of drugs for the treatment of elderly patients with coronary heart disease (CHD) in the field of clinical medicine. Objective to explore the clinical efficacy and safety of different statins in the treatment of senile coronary heart disease (CHD), and to provide clinical reference for clinicians to use statins in the treatment of senile coronary heart disease (CHD). Materials and methods 300 elderly patients with coronary heart disease were randomly divided into two groups, 150 cases in each group. After three months of treatment, the efficacy and safety of lovastatin and Atto vastatin were compared. Results statins in the treatment of elderly patients with coronary heart disease can effectively reduce the total cholesterol content (mmol/L), fasting blood glucose content (mmol/L), c sensitive reactive protein (mg/L) and low density lipoprotein (mg/L) index), and the adverse drug reaction is lower. It is a safe and effective treatment. Conclusion in general, different kinds of statins can be used to treat senile patients with coronary heart disease. Different kinds of statins can reduce blood lipid, improve cardiovascular function and reduce the probability of coronary heart disease in short time. It is worth popularizing in elderly patients with coronary heart disease.
【学位授予单位】：吉林大学
【学位级别】：硕士
【学位授予年份】：2017
【分类号】：R541.4

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