动脉粥样硬化兔解郁合剂治疗前后血脂水平变化

发布时间：2018-10-18 13:53

【摘要】：目的观察用解郁合剂治疗的对动脉粥样硬化模型兔血脂的变化。方法将40只新西兰兔随机分为对照组、模型组、阿托伐他汀组、解郁合剂高剂量组、解郁合剂低剂量组,各8只。对照组给予常规饲料饲养。模型组、阿托伐他汀组、解郁合剂高剂量组、解郁合剂低剂量组采用球囊法损伤腹主动脉内皮加高脂饲料喂养建立兔动脉粥样硬化模型,然后分别给予1.4 mg/kg阿托伐他汀钙、10.5 mg/kg(3倍临床等效剂量)解郁合剂、3.5 mg/kg(临床等效剂量)解郁合剂,继续用高脂饲料喂养4周。采血分离血清,采用酶法检测总胆固醇(TC)、甘油三酯(TG)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)、载脂蛋白A1、载脂蛋白B、脂蛋白a。结果与模型组相比,阿托伐他汀组、解郁合剂高剂量组、解郁合剂低剂量组兔血清TC、TG、LDL-C、载脂蛋白B、脂蛋白(a)下降(P均0.05);各组HDL-C、载脂蛋白A1相比,P均0.05。阿托伐他汀组、解郁合剂高剂量组、解郁合剂低剂量组兔各项血脂指标相比,P均0.05。结论解郁合剂可以降低动脉粥样硬化模型兔TC、TG、LDL-C、载脂蛋白B、脂蛋白a水平。在临床等效剂量基础上增加解郁合剂用量不会提高降血脂效果。
[Abstract]:Objective to observe the changes of blood lipid in atherosclerosis model rabbits treated with Jieyu mixture. Methods 40 New Zealand rabbits were randomly divided into control group, model group, Atto vastatin group, high dose group of Jieyu mixture, and low dose group of Jieyu mixture, each with 8 rats. The control group was fed with conventional feed. Model group, Atto vastatin group, high dose group of Jieyu mixture and low dose group of Jieyu mixture were used to establish rabbit model of atherosclerosis by balloon injury of abdominal aorta endothelium and high fat diet. Then 1. 4 mg/kg Atto calcium, 10. 5 mg/kg (3 times clinical equivalent dose), 3. 5 mg/kg (clinical equivalent dose) and 3. 5 mg/kg (clinical equivalent dose) were given respectively, and fed with high fat diet for 4 weeks. Serum samples were collected, and total cholesterol (TC), triglyceride (TG), high density lipoprotein cholesterol (HDL-C), low density lipoprotein cholesterol (LDL-C), apolipoprotein A1, apolipoprotein B, lipoprotein a were detected by enzyme method. Results compared with the model group, the serum TC,TG,LDL-C, apolipoprotein B and lipoprotein (a) decreased in the Atto vastatin group, the high dose group of Jieyu mixture and the low dose group of Jieyu mixture (P 0.05), and the levels of HDL-C, apolipoprotein A1 were all 0.05 in each group. Compared with each other, the indexes of blood lipid in the group of Atto vastatin, the group of high dose of Jieyu mixture and the group of low dose of Jieyu mixture were 0.05. Conclusion Jieyu mixture can reduce the levels of TC,TG,LDL-C, apolipoprotein B and lipoprotein a in atherosclerotic rabbits. Increasing the dosage of Jieyu mixture on the basis of clinical equivalent dose will not improve the effect of lowering blood lipid.
【作者单位】：山东省中医药研究院附属医院;
【基金】：山东省中医药科技发展计划项目(2014ZYKJFZ005263)
【分类号】：R543.5

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