单纯抗凝及其与接触性导管溶栓联合抗凝治疗下肢深静脉血栓的效果比较

发布时间：2018-10-20 19:39

【摘要】：目的:对比单纯抗凝(anticoagulation,AC)与接触性导管溶栓联合抗凝(catheter-directed thrombolysis,CDT)治疗下肢深静脉血栓(DVT)的效果。方法:选取本院2011年5月-2013年9月收治的139例DVT患者,根据随机数字表法分为AC组(n=66)与CDT+AC组(n=73),观察两组溶栓效果、不良反应、血栓后综合症(PTS)和生活质量情况。结果:两组患者在治疗期间和治疗结束后均无严重的不良反应发生,其中CDT组有2例穿刺处血肿,1例血尿,2例牙龈出血;AC组有1例牙龈出血,1例血肿。与AC组相比,CDT+AC组患者中Ⅰ级溶解的人数显著降低(60.61%vs 9.59%)(P0.05),Ⅲ级溶解的人数显著升高(7.57%vs 49.31%)(P0.05)。随访期间,两组的PTS发病率均呈逐渐增高趋势,但无1例患者出现重度PTS。CDT+AC组患者在第12个月和18个月时的PTS发病率均较AC组显著降低(17.81%vs 33.33%,24.66%vs 43.94%)(P0.05)。与AC组相比,CDT+AC组在第6个月、12个月及18个月时生理职能和活力评分均显著升高(P0.05)。结论:接触性导管溶栓联合单纯抗凝治疗下肢深静脉血栓形成疗效显著,安全性高,而且有利于患者生活质量的改善。
[Abstract]:Objective: to compare the effect of simple anticoagulant (anticoagulation,AC) and contact catheter thrombolysis combined with anticoagulation (catheter-directed thrombolysis,CDT) in the treatment of lower extremity deep venous thrombosis (DVT). Methods: one hundred and nine patients with DVT were selected from May 2011 to September 2013 in our hospital. According to the random digital table, they were divided into two groups: AC group (n = 66) and CDT AC group (n = 73). The effect of thrombolytic therapy, adverse reaction, (PTS) and quality of life were observed. Results: there were no serious adverse reactions during and after treatment in the two groups. In CDT group, 2 cases had hematoma, 1 case had hematuria, 2 cases had gingival hemorrhage, and 1 case had gingival hemorrhage and 1 case had hematoma in AC group. Compared with AC group, the number of grade 鈪，

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