载脂蛋白C3基因rs5128多态性与不同体质指数冠心病患者血脂水平及冠状动脉狭窄程度的相关性
发布时间：2018-10-21 08:55
【摘要】：目的探讨中国汉族人群载脂蛋白C3(ApoC3)基因rs5128多态性与不同体质指数(BMI)冠心病(CHD)患者血脂水平及冠状动脉狭窄程度的相关性。方法根据BMI将312例CHD患者分为正常体重组(205例)和超重/肥胖组(107例)。收集所有患者的生理生化资料和冠状动脉造影数据,采用Gensini评分法评价CHD患者的冠状动脉狭窄程度。提取外周血白细胞DNA并应用聚合酶链反应-限制性片段长度多态性法对ApoC3rs5128多态性分型。结果超重/肥胖组体重、BMI、高血压患病率、甘油三酯(TG)、脂蛋白a、TG/高密度脂蛋白胆固醇(HDLC)、总胆固醇(TC)/HDLC、低密度脂蛋白胆固醇(LDLC)/HDLC和载脂蛋白B100(ApoB100)/载脂蛋白AI(ApoAⅠ)水平高于正常体重组,HDLC和ApoAⅠ水平低于正常体重组(P0.05)。在正常体重组中,G等位基因携带者高血压患病率显著高于CC基因型患者(P0.05);在超重/肥胖组中,G等位基因携带者TG和TG/HDLC水平显著高于CC基因型患者(P0.05)。在正常体重组和超重/肥胖组中,rs5128多态性基因型和等位基因频率在不同冠状动脉狭窄程度亚组中的分布差异无统计学意义(P0.05)。结论在超重/肥胖CHD患者中,rs5128多态性G等位基因与血浆TG和TG/HDLC水平升高显著相关,但与冠状动脉狭窄程度无明显关联。
[Abstract]:Objective to investigate the relationship between rs5128 polymorphism of apolipoprotein C3 (ApoC3) gene and serum lipids and coronary artery stenosis in patients with coronary heart disease (CHD) with different body mass index (BMI). Methods according to BMI, 312 patients with CHD were divided into normal weight group (205 cases) and overweight / obesity group (107 cases). The physiological and biochemical data and coronary angiography data of all patients were collected and the degree of coronary artery stenosis in CHD patients was evaluated by Gensini scoring method. DNA was extracted from peripheral blood leukocytes and genotyped by polymerase chain reaction-restriction fragment length polymorphism (ApoC3rs5128). Results the prevalence of BMI, hypertension and body weight in overweight / obesity group was higher than that in control group. The levels of TG / HDL-C (HDLC), total cholesterol (TC) / HDLC, low density lipoprotein cholesterol (LDLC) / HDLC) and apolipoprotein B100 (ApoB100) / apolipoprotein AI (ApoA 鈪，
本文编号：2284611
[Abstract]:Objective to investigate the relationship between rs5128 polymorphism of apolipoprotein C3 (ApoC3) gene and serum lipids and coronary artery stenosis in patients with coronary heart disease (CHD) with different body mass index (BMI). Methods according to BMI, 312 patients with CHD were divided into normal weight group (205 cases) and overweight / obesity group (107 cases). The physiological and biochemical data and coronary angiography data of all patients were collected and the degree of coronary artery stenosis in CHD patients was evaluated by Gensini scoring method. DNA was extracted from peripheral blood leukocytes and genotyped by polymerase chain reaction-restriction fragment length polymorphism (ApoC3rs5128). Results the prevalence of BMI, hypertension and body weight in overweight / obesity group was higher than that in control group. The levels of TG / HDL-C (HDLC), total cholesterol (TC) / HDLC, low density lipoprotein cholesterol (LDLC) / HDLC) and apolipoprotein B100 (ApoB100) / apolipoprotein AI (ApoA 鈪，
本文编号：2284611
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