肺动脉高压患者的现状调查及病因构成

发布时间：2018-10-21 20:11

【摘要】：目的:调查成人肺动脉高压(pulmonary hypertension,PH)患者的人口学特征和不同病因之间的构成比。方法:回顾性调查2010年1月至2014年12月中南大学湘雅二医院经临床诊断或经胸多普勒超声、右心导管检查诊断为PH的2 508例成人住院患者,收集其临床资料,包括研究对象的性别、年龄、原发病等,并进行统计学分析。结果:本次调查中PH患者人数逐年上升,患者年龄为47(18~93)岁;男性933例(37.20%),男:女约为1:1.69(P0.05)。其中,第I类PH(动脉型PH)与第II类PH(左心疾病相关的PH)以女性多见(70%),第III类(呼吸系统疾病或缺氧相关性PH)以男性多见(74.5%)。在本次调查中,第I类PH 896例(35.73%)、第II类PH 1163例(46.37%)、第III类PH 411例(16.39%)、第IV类PH(慢性血栓性PH)32例(1.27%)、第V类PH(原因不明或多种因素所致PH)6例(0.24%)。发病例数居前7位的PH原发病依次为风湿性心脏病(1 090例,43.48%)、先天性心脏病(692例,27.60%)、慢性阻塞性肺疾病(358例,14.28%)、结缔组织相关性疾病(156例,6.22%)、瓣膜性心脏病(66例,2.63%)、特发性PH(46例,1.83%)、肺栓塞(27例,1.08%)。结论:在本次调查中成人PH发病的高峰年龄阶段是41~50岁,其中以女性多见,且第I类及第II类PH以女性多见,第III类PH以男性多见;风湿性心脏病及先天性心脏病是目前中国PH最常见的病因;慢性阻塞性肺疾病是第III类PH最常见病因,且此类患者年龄较大。
[Abstract]:Objective: to investigate the demographic characteristics of adult patients with pulmonary hypertension (pulmonary hypertension,PH) and the ratio of different etiological factors. Methods: from January 2010 to December 2014, 2 508 adult inpatients with PH diagnosed by clinical diagnosis or transthoracic Doppler ultrasound and right cardiac catheterization were investigated retrospectively, and their clinical data were collected. Including sex, age, primary disease and so on, and carries on the statistical analysis. Results: the number of patients with PH increased year by year, the age of the patients was 47 (1893) years, 933 cases (37.20%) of males and 1: 1.69 (P0.05) of males and females. Among them, type I PH (arterial type PH) and II class PH (PH associated with left ventricular disease) were more common in females (70%), and III (respiratory diseases or hypoxic associated PH) were more common in males (74.5%). There were 896 cases (35.73%) of type I PH, 1163 cases (46.37%) of II PH, 411 cases (16.39%) of III PH, 32 cases (1.27%) of IV PH (chronic thrombotic PH) and 6 cases (0.24%) of type V PH (PH caused by unknown or multiple factors). Rheumatic heart disease (1,090 cases, 43.48%), congenital heart disease (692 cases, 27.60%), chronic obstructive pulmonary disease (358 cases, 14.28%), connective tissue related disease (156 cases, 6.22%), valvular heart disease (66 cases, 2.63%), idiopathic heart disease (Idiopathic) were the first 7 cases of PH. PH (46 cases, 1.83%), pulmonary embolism (27 cases, 1.08%). Conclusion: in this investigation, the peak age of adult PH is 41 to 50 years old, and most of them are female, type I and II PH are female, and III PH is male. Rheumatic heart disease and congenital heart disease are the most common etiology of PH in China at present, chronic obstructive pulmonary disease is the most common cause of III PH, and these patients are older.
【作者单位】：中南大学湘雅二医院呼吸内科湖南省循证医学研究中心;
【基金】：国家科技支撑计划(2013BAI09B104) 中南大学硕士生自主探索创新项目(2015zzts307)~~
【分类号】：R544.1

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