血浆可溶性尿激酶型纤溶酶原激活物受体水平与急性冠状动脉综合征的相关性及其影响因素的研究

发布时间：2018-10-22 14:00

【摘要】：目的:探讨血浆可溶性尿激酶型纤溶酶原激活物受体(su PAR)水平与急性冠状动脉综合征(ACS)患者冠状动脉病变程度的相关性及其影响因素。方法:收集兰州大学第一医院心脏中心2015-03至2016-09因胸痛住院321例患者的基本资料,根据临床表现、实验室检查及冠状动脉造影结果分为急性冠状动脉综合征(ACS)组228例,冠状动脉造影正常的对照组93例,ELISA法检测血浆su PAR、高敏C反应蛋白(hs-CRP)水平并进行统计学分析。结果:多因素校正后,ACS组的血浆su PAR水平明显高于对照组[OR=0.104,95%CI:0.048~0.223,P0.01],在ACS组中随着Gensini积分增高,血浆su PAR水平逐渐升高;根据ROC曲线获得su PAR预测ACS对应界值:1.8μg/L,敏感性0.732,特异性0.710,多元线性回归分析提示吸烟、Gensini积分、血尿酸是影响血浆su PAR水平主要因素。结论:升高的血浆su PAR水平与ACS患者冠状动脉狭窄程度相关,这种关系优于传统炎症标记物hs-CRP,有可能成为预测ACS患者冠状动脉狭窄程度及危险分层的新的生物标记物。
[Abstract]:Aim: to investigate the relationship between plasma soluble urokinase type plasminogen activator receptor (su PAR) and coronary artery disease in patients with acute coronary syndrome (ACS). Methods: the basic data of 321 patients with chest pain were collected from the heart center of the first Hospital of Lanzhou University from March to September 2015-2016.According to the clinical manifestation, laboratory examination and coronary angiography results, the patients were divided into two groups: (ACS) group (n = 228), acute coronary syndrome group (n = 228). The plasma levels of su PAR, Gao Min C reactive protein (hs-CRP) were measured by ELISA method in 93 patients with normal coronary arteriography. Results: after multivariate correction, the plasma su PAR level in ACS group was significantly higher than that in control group [OR=0.104,95%CI:0.048~0.223,P0.01]. In ACS group, the plasma su PAR level gradually increased with the increase of Gensini score. According to the ROC curve, the corresponding value of ACS predicted by su PAR was 1.8 渭 g / L, sensitivity was 0.732, specificity was 0.710. Multiple linear regression analysis showed that smoking, Gensini score and uric acid were the main factors affecting plasma su PAR level. Conclusion: the elevated plasma su PAR level is correlated with the degree of coronary artery stenosis in patients with ACS, which may be a new biomarker for predicting the severity and risk stratification of coronary artery stenosis in ACS patients, which is superior to the traditional inflammatory marker hs-CRP,.
【作者单位】：兰州大学第一临床医学院兰州大学第一医院心脏中心;
【基金】：甘肃省自然科学基金项目(1308RJZA208)
【分类号】：R541.4

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