动脉内流-固耦合作用下两相血流动力学数值模拟

发布时间：2018-10-30 09:42

【摘要】：目的研究流-固耦合作用下左冠状动脉内一个心动周期典型时点两相血流动力学分布及红细胞分布,探索左冠状动脉粥样斑块形成与发展机制。方法将血液视为两相流体,基于血液与血管壁间流-固耦合作用,采用计算流体力学方法对左冠状动脉内两相血流进行瞬态数值模拟,研究一个心动周期内典型时点左冠状动脉内血流分布特性,血流动力学特性参数与动脉粥样斑块形成的相互作用关系。结果左冠状动脉回旋支远段和钝缘支近心端外侧存在低速涡流区,该区域内壁面切应力和红细胞体积分数均较小,血流流态复杂。结论壁面切应力较小的低速涡流区易产生脂质浓度极化、大分子物质沉积,红细胞较少区域易发生缺氧,引起血管壁通透性增加和内膜损伤,激活免疫系统,导致血管壁物质累积和内膜生长,从而易诱发动脉粥样硬化斑块形成。
[Abstract]:Objective to study the biphasic hemodynamic distribution and erythrocyte distribution at a typical time point in a cardiac cycle of left coronary artery under fluid-solid coupling, and to explore the mechanism of atherosclerotic plaque formation and development in the left coronary artery. Methods Blood was regarded as a two-phase fluid. Based on the interaction between blood and blood vessel wall, the transient numerical simulation of two-phase blood flow in left coronary artery was carried out by computational fluid dynamics (CFD). To study the relationship between the characteristics of left coronary blood flow distribution, hemodynamic parameters and atherosclerotic plaque formation at a typical time point in a cardiac cycle. Results there was a low velocity eddy current region in the distal segment of the circumflex branch of the left coronary artery and the lateral side of the proximal cardiac end of the obtuse marginal branch. The wall shear stress and the RBC volume fraction in the region were small and the blood flow pattern was complex. Conclusion low velocity eddy current region with low wall shear stress is prone to lipid concentration polarization, macromolecule deposition, hypoxia in less red blood cells, increased vascular permeability and intimal injury, and activation of immune system. This leads to the accumulation of materials in the wall and the growth of intima, which can easily induce atherosclerotic plaque formation.
【作者单位】：南昌大学机电工程学院;南昌大学第一附属医院心血管科;
【基金】：国家自然科学基金(51165031)
【分类号】：R543.5

【相似文献】