哈萨克族原发性高血压患者肾功能减退的相关因素分析

发布时间：2018-10-30 20:33

【摘要】：目的探讨新疆哈萨克族原发性高血压患者肾小球滤过功能减退的相关因素。方法随机抽取新疆沙湾县、玛纳斯县等哈萨克族聚集地高血压患者231例,利用简化肾脏病膳食改良试验方程估算肾小球滤过率(e GFR);根据e GFR水平将高血压患者分成肾功能组减退组85例和肾功能正常组146例,检测两组血肌酐(Cr)、尿酸(UA)、总胆固醇(TC)、甘油三酯(TG)、空腹血糖(FPG)、低密度脂蛋白胆固醇(LDL-C)、高密度脂蛋白胆固醇(HDL-C)、同型半胱氨酸(Hcy)等生化指标,同时测量其体质量指数(BMI)、腰臀比(WHR)、腰身比(WHtR)。采用Pearson相关及二元Logistics回归分析法分析影响肾功能减退的相关因素。结果两组年龄、血压、BMI、血Ccr、UA、TG、FPG、LDL-C、Hcy比较差异有统计学意义(P均0.05)。高血压患者e GFR与HDL-C呈正相关(P0.05),与BMI、TG、LDL-C、UA、SBP、DBP呈负相关(P均0.05)。矫正性别、年龄,血压等因素后,二元Logistic回归示UA、BMI、LDL-C是高血压患者肾功能减退的独立危险因素(OR分别为1.010、0.642、2.067,P均0.05)。结论新疆哈萨克族原发性高血压患者肾功能减退是血压、血脂、UA、BMI等因素共同作用的结果。
[Abstract]:Objective to investigate the related factors of glomerular filtration dysfunction in Kazak essential hypertension patients in Xinjiang. Methods A total of 231 patients with hypertension were randomly selected from Shawan County, Manas County and other Kazakh communities in Xinjiang. The glomerular filtration rate (e GFR);) was estimated by using the simplified diet improvement test equation of kidney disease. According to the level of e GFR, hypertensive patients were divided into two groups: renal dysfunction group (n = 85) and normal renal function group (n = 146). Serum creatinine, (Cr), uric acid, total cholesterol, (TC), triglyceride, (TG), fasting blood glucose (FPG),) were measured in both groups. Low density lipoprotein cholesterol (LDL-C), high density lipoprotein cholesterol (HDL-C) and homocysteine (Hcy) were measured. The body mass index (BMI), waist-hip ratio (WHR), waist ratio (WHtR).) were measured. The correlation factors of renal dysfunction were analyzed by Pearson correlation and binary Logistics regression analysis. Results there were significant differences in age, blood pressure and BMI, Ccr,UA,TG,FPG,LDL-C,Hcy between the two groups (all P 0. 05). E GFR was positively correlated with HDL-C (P 0.05) and negatively correlated with BMI,TG,LDL-C,UA,SBP,DBP (P 0.05). After sex, age and blood pressure were corrected, binary Logistic regression showed that UA,BMI,LDL-C was an independent risk factor for renal dysfunction in hypertensive patients (OR = 1.010 0. 642 卤2. 067). Conclusion Renal dysfunction in Xinjiang Kazak patients with essential hypertension is the result of blood pressure, blood lipid and UA,BMI.
【作者单位】：石河子大学医学院;石河子大学医学院第一附属医院;
【基金】：国家自然科学基金资助项目(81460075)
【分类号】：R544.11;R692

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