心脉康片对冠心病介入治疗术后炎症因子水平的影响

发布时间：2018-11-02 08:56

【摘要】：目的:观察中成药心脉康片对冠心病介入治疗术后炎症因子水平的影响,探讨其治疗介入治疗术后冠心病可能的作用机制,从而为中西药联合治疗介入治疗术后冠心病提供新的思路和方法。方法:将采取支架植入术治疗的冠心病患者60例纳入研究,随机分为治疗组和对照组,每组各30例,对照组给予西药常规治疗,治疗组在西药基础上加用心脉康片,检测两组患者支架植入术前6小时、术后12小时、治疗1个月后血清超敏C反应蛋白、白细胞介素-6、肿瘤坏死因子-α的水平,并进行比较,探讨介入治疗操作对炎症反应的影响以及心脉康片对介入治疗术后炎症反应的抑制作用。结果:(1)将两组术后12h炎症因子与术前6h比较,发现术后三种炎症因子水平均明显升高(表5,表6,表7)。(2)将治疗1个月后两组炎症因子水平与术前6h比较,发现治疗结束时两组患者三种炎症因子水平均明显下降(表8,表9,表10)。(3)对比治疗组和对照组治疗1个月后血清炎症因子下降的幅度,治疗组hs-CRP、IL-6较对照组下降更为明显,差异有统计学意义。而两组TNF-α下降程度无显著差异(表11)。结论:冠心病介入治疗术后的药物治疗方案均具有一定抗炎作用,这可能是其实现预防血管病变进展及再狭窄发生的作用机制之一。而心脉康片联合西药治疗则具有更强的抗炎效果,因此中成药心脉康片应用于冠心病介入治疗术后具有可行性,且能够给病人带来获益。
[Abstract]:Objective: to observe the effect of Xinmai Kang tablet, a traditional Chinese patent medicine, on the level of inflammatory factors after interventional therapy of coronary heart disease (CHD), and to explore the possible mechanism of its effect on coronary heart disease after interventional therapy. Therefore, it provides a new way of thinking and method for coronary heart disease after interventional therapy with traditional Chinese medicine and western medicine. Methods: sixty patients with coronary heart disease treated by stent implantation were randomly divided into treatment group (n = 30) and control group (n = 30). The control group was treated with routine western medicine, and the treatment group was treated with Xinmai Kang tablet on the basis of western medicine. The serum levels of serum hypersensitive C-reactive protein, interleukin-6, tumor necrosis factor- 伪 were measured 6 hours before stent implantation and 12 hours after stent implantation in both groups. To investigate the effect of interventional therapy on inflammatory reaction and the inhibitory effect of Xinmaikang tablet on inflammatory response after interventional therapy. Results: (1) the levels of inflammatory cytokines in the two groups were significantly increased (table 5, table 6, and table 7). (2) at 12 hours after operation compared with 6 hours before operation (Table 5, Table 6, and Table 7). (2). The levels of inflammatory cytokines in the two groups were compared with those in 6 hours preoperatively after one month of treatment. It was found that at the end of treatment, the levels of three kinds of inflammatory factors in both groups were significantly decreased (table 8, table 9, table 10). (3). The levels of serum inflammatory factors in the treatment group and the control group were significantly decreased after one month of treatment. The hs-CRP, in the treatment group was significantly lower than that in the control group. The decrease of IL-6 was more obvious than that of the control group, and the difference was statistically significant. There was no significant difference in the degree of TNF- 伪 decrease between the two groups (Table 11). Conclusion: the drug therapy after coronary intervention therapy has some anti-inflammatory effect, which may be one of the mechanisms to prevent the progression and restenosis of coronary artery disease. Xinmaikang tablet combined with western medicine has stronger anti-inflammatory effect, so it is feasible to apply Xinmai Kang tablet to coronary heart disease intervention therapy, and can benefit patients.
【学位授予单位】：广州中医药大学
【学位级别】：硕士
【学位授予年份】：2017
【分类号】：R541.4

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