14例硼替佐米致心力衰竭文献分析

发布时间：2018-11-06 17:48

【摘要】：目的:分析硼替佐米致心力衰竭的发生规律及特点,为安全用药提供参考。方法:检索国内外硼替佐米致心力衰竭个案报道文献进行分析。结果:共检索到硼替佐米致心力衰竭个案报道11篇,涉及14例患者,男性8例,女性6例,年龄≥60岁的老年患者7例,有心血管疾病基础疾病及接受过蒽环类药物治疗分别有5例,有7例在第4次化疗周期后发生心力衰竭。硼替佐米致心力衰竭临床表现主要为呼吸困难,心胸比率增大,左、右室内径增加,LVEF下降,BNP增高。结论:有心血管疾病基础疾病及蒽环类药物使用史可能更易发生心力衰竭,应加强硼替佐米致心力衰竭监测,重点防治,减少其发生。
[Abstract]:Objective: to analyze the occurrence and characteristics of bortezomib induced heart failure in order to provide reference for safe drug use. Methods: to search the literature of bortezomib induced heart failure at home and abroad. Results: a total of 11 cases of bortezomib induced heart failure were reported, involving 14 patients, 8 males, 6 females, 7 elderly patients aged more than 60 years. There were 5 cases of cardiovascular disease and 5 cases of anthracycline treatment, and 7 cases developed heart failure after the fourth chemotherapy cycle. The clinical manifestations of bortezomib in heart failure were dyspnea, cardiothoracic ratio, left and right ventricular diameter, LVEF and BNP. Conclusion: heart failure may be more likely to occur in patients with underlying cardiovascular diseases and anthracycline use. The monitoring of heart failure caused by bortezomib should be strengthened to focus on prevention and treatment and to reduce the occurrence of heart failure.
【作者单位】：安徽省蚌埠市第三人民医院药学部;
【分类号】：R541.6

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