针刺联合前列地尔治疗下肢动脉斑块的疗效观察
发布时间：2018-11-06 20:48
【摘要】：目的通过观察前列地尔、针刺联合前列地尔治疗下肢动脉斑块患者的疗效差异,从而评价针刺联合前列地尔治疗下肢动脉斑块的临床疗效和安全性。研究方法1.将2013年6月-2014年6月安徽中医药大学第二附属医院收治的40例符合纳入标准的下肢动脉斑块患者,按照随机数字表法分为治疗组(针刺联合前列地尔组)和对照组(前列地尔组)各20例。2.针刺联合前列地尔治疗组:患者取坐位,常规消毒后,采用单手进针法将天协牌针灸针快速刺入患者以下穴位:足三里、三阴交、悬钟、丰隆,均为双侧。进针后行手法催气,以有酸麻胀或有触电感为佳,得气后停止行针,留针,中间隔20分钟行针一次,治疗时间为40分钟,每日1次,并将前列地尔注射液l0μg(与对照组药外包装完全一致)溶解在10ml生理盐水中,然后缓慢静脉推注,每日给药1次,连续给药14d。受试者实际用药量80%研究所需用药量,视为脱落。3.前列地尔对照组:将前列地尔注射液l0μg(哈药集团生物工程有限公司生产,国药准字H20084565)溶解在10ml生理盐水中,然后缓慢静脉推注,每日给药1次,连续给药14d。受试者实际用药量80%研究所需用药量,视为脱落。4.两组均以14次为1个疗程,疗程间休息7天再进入下一个疗程,治疗2个疗程。治疗前后均检查患者双下肢动脉彩超,对两组患者进行疗效评价;并且6个月后再次行下肢动脉彩超检查判断其疗效。最后将采集的数据用统计软件SPSS17.0进行分析。结果共纳入40例完成实验。针刺联合前列地尔组治疗后观察指标较治疗前有显著差异(P0.01),前列地尔组治疗后较前有差异(P0.05)。两组治疗前后下肢动脉中内膜厚度及斑块面积的差异有统计学意义(P0.05),且治疗组优于对照组。6个月后针刺联合前列地尔治疗组与前列地尔对照组比较有显著差异(P0.01)。结论针刺足三里、三阴交、悬钟、丰隆穴联合前列地尔注射液和单用前列地尔注射液均能改变下肢动脉斑块的大小,降低下肢动脉中内膜厚度,但是针刺足三里、三阴交、悬钟、丰隆穴联合前列地尔注射液组的效果明显优于单用前列地尔注射液组,且针刺治疗组维持疗效优于对照组。所以针刺足三里、三阴交、悬钟、丰隆穴能减小下肢动脉斑块的大小、降低下肢动脉中内膜厚度,从而减少梗塞的风险。
[Abstract]:Objective to evaluate the efficacy and safety of alprostadil combined with alprostadil in the treatment of arterial plaque of lower extremity. Method 1. From June 2013 to June 2014, 40 patients with arterial plaques of lower extremity who were admitted to the second affiliated Hospital of Anhui University of traditional Chinese Medicine, According to random number table method, 20 cases in treatment group (acupuncture combined with alprostadil group) and 20 cases in control group (alprostadil group) were divided into treatment group (n = 20) and control group (n = 20). Acupuncture combined with alprostadil treatment group: the patients took the sitting position, after routine disinfection, the Tianxie acupuncture needle was quickly punctured into the following points: Zusanli, Sanyinjiao, suspension bell, Fenglong, both sides. After entering the needle, the best way to promote qi is to have acid swelling or electric shock. After getting qi, stop the needle, keep the needle, once every 20 minutes, treatment time is 40 minutes, once a day, Alprostadil injection 10 渭 g (exactly the same as the control group) was dissolved in 10ml saline, and then was injected intravenously once a day for 14 days. The actual amount of medicine used in the study was 80%, which was regarded as shedding. Alprostadil control group: L0 渭 g of alprostadil injection (produced by Harbin Pharmaceutical Group Bioengineering Co., Ltd., H20084565) was dissolved in normal saline of 10ml, then slowly injected intravenously, once a day, continuously for 14 days. The actual amount of medicine used in the study was 80%, which was regarded as shedding. 4. 4. The two groups were treated with 14 times as a course of treatment, rest 7 days between the courses and then enter the next course of treatment, 2 courses of treatment. Before and after treatment, the two lower extremity arteries were examined by color Doppler ultrasound to evaluate the curative effect of the two groups, and six months later, the lower extremity artery color ultrasound was performed again to judge the curative effect. Finally, the collected data is analyzed by SPSS17.0. Results A total of 40 cases were included in the experiment. Acupuncture combined with alprostadil group after treatment there was a significant difference in the observation index (P0.01), alprostadil group after treatment than before the difference (P0.05). There were significant differences in intimal thickness and plaque area between the two groups before and after treatment (P0.05). After 6 months of acupuncture combined with alprostadil, there was significant difference between the treatment group and the alprostadil control group (P0.01). Conclusion Acupuncture of Zusanli, Sanyinjiao, Xuanzhong, Fenglong acupoint combined with alprostadil injection and alprostadil injection alone can change the size of arterial plaque of lower extremity and decrease the thickness of intima of lower extremity artery, but acupuncture at Zusanli and Sanyinjiao can change the size of arterial plaque of lower extremity. The effect of Xuanzhong, Fenglong acupoint combined with alprostadil injection group was better than that of single alprostadil injection group, and the maintenance effect of acupuncture group was better than that of control group. Therefore, acupuncture at Zusanli, Sanyinjiao, Xuanzhong and Fenglong points can reduce the size of arterial plaques of the lower extremities, reduce the intimal thickness of the arteries of the lower extremities, and thus reduce the risk of infarction.
【学位授予单位】：安徽中医药大学
【学位级别】：硕士
【学位授予年份】：2015
【分类号】：R543.5
本文编号：2315432
[Abstract]:Objective to evaluate the efficacy and safety of alprostadil combined with alprostadil in the treatment of arterial plaque of lower extremity. Method 1. From June 2013 to June 2014, 40 patients with arterial plaques of lower extremity who were admitted to the second affiliated Hospital of Anhui University of traditional Chinese Medicine, According to random number table method, 20 cases in treatment group (acupuncture combined with alprostadil group) and 20 cases in control group (alprostadil group) were divided into treatment group (n = 20) and control group (n = 20). Acupuncture combined with alprostadil treatment group: the patients took the sitting position, after routine disinfection, the Tianxie acupuncture needle was quickly punctured into the following points: Zusanli, Sanyinjiao, suspension bell, Fenglong, both sides. After entering the needle, the best way to promote qi is to have acid swelling or electric shock. After getting qi, stop the needle, keep the needle, once every 20 minutes, treatment time is 40 minutes, once a day, Alprostadil injection 10 渭 g (exactly the same as the control group) was dissolved in 10ml saline, and then was injected intravenously once a day for 14 days. The actual amount of medicine used in the study was 80%, which was regarded as shedding. Alprostadil control group: L0 渭 g of alprostadil injection (produced by Harbin Pharmaceutical Group Bioengineering Co., Ltd., H20084565) was dissolved in normal saline of 10ml, then slowly injected intravenously, once a day, continuously for 14 days. The actual amount of medicine used in the study was 80%, which was regarded as shedding. 4. 4. The two groups were treated with 14 times as a course of treatment, rest 7 days between the courses and then enter the next course of treatment, 2 courses of treatment. Before and after treatment, the two lower extremity arteries were examined by color Doppler ultrasound to evaluate the curative effect of the two groups, and six months later, the lower extremity artery color ultrasound was performed again to judge the curative effect. Finally, the collected data is analyzed by SPSS17.0. Results A total of 40 cases were included in the experiment. Acupuncture combined with alprostadil group after treatment there was a significant difference in the observation index (P0.01), alprostadil group after treatment than before the difference (P0.05). There were significant differences in intimal thickness and plaque area between the two groups before and after treatment (P0.05). After 6 months of acupuncture combined with alprostadil, there was significant difference between the treatment group and the alprostadil control group (P0.01). Conclusion Acupuncture of Zusanli, Sanyinjiao, Xuanzhong, Fenglong acupoint combined with alprostadil injection and alprostadil injection alone can change the size of arterial plaque of lower extremity and decrease the thickness of intima of lower extremity artery, but acupuncture at Zusanli and Sanyinjiao can change the size of arterial plaque of lower extremity. The effect of Xuanzhong, Fenglong acupoint combined with alprostadil injection group was better than that of single alprostadil injection group, and the maintenance effect of acupuncture group was better than that of control group. Therefore, acupuncture at Zusanli, Sanyinjiao, Xuanzhong and Fenglong points can reduce the size of arterial plaques of the lower extremities, reduce the intimal thickness of the arteries of the lower extremities, and thus reduce the risk of infarction.
【学位授予单位】：安徽中医药大学
【学位级别】：硕士
【学位授予年份】：2015
【分类号】：R543.5
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