他汀类药物对动脉粥样硬化的疗效研究
发布时间：2018-11-26 11:44
【摘要】：目的 探讨他汀类药物对动脉粥样硬化患者的疗效及其作用机制。方法 选取该院收治的动脉粥样硬化患者104例,随机分为对照组、辛伐他汀组、普伐他汀组、阿托伐他汀组,分别给药治疗。测定4组患者在治疗前和治疗6个月后的的三酰甘油(TG)、总胆固醇(TC)、高密度脂蛋白胆固醇(HDL-C)及低密度脂蛋白胆固醇(LDC-C)水平,同时测定其双侧总动脉内膜-中层的厚度、粥样斑块的最大直径和厚度,用分光光度计检测血液中一氧化氮NO和一氧化氮合成酶(NOS)的含量,并统计患者出现不良反应的例数。结果 实验组在治疗后TG、TC和LDC-C值呈现下降趋势,HDL-C值呈上升趋势,与对照组比较,差异有统计学意义(P0.05),而辛伐他汀组、普伐他汀组、阿托伐他汀组比较,差异无统计学意义(P0.05)。实验组治疗有效率高达70.08%,与对照组比较,差异有统计学意义(P0.05)。实验组的IMT及斑块的最大直径与治疗前比较,差异有统计学意义(P0.05),而各组间比较,差异无统计学意义(P0.05)。实验组NO及NOS水平与治疗前及对照组比较,差异有统计学意义(P0.05),实验组NO和NOS水平升高。随访结果表明,他汀类药物在使用过程中安全有效。结论 他汀类药物治疗动脉粥样硬化安全、有效、可靠,并能有效调节患者血液中NO、NOS含量,值得在临床上大力推广。
[Abstract]:Objective to investigate the effect of statins on atherosclerosis and its mechanism. Methods 104 patients with atherosclerosis were randomly divided into control group, simvastatin group, pravastatin group and Atto vastatin group. The levels of triglyceride (TG), total cholesterol (TC), high density lipoprotein cholesterol (HDL-C) and low density lipoprotein cholesterol (LDC-C) were measured before and 6 months after treatment in the four groups. At the same time, the thickness of intima-media, the maximum diameter and thickness of atherosclerotic plaques were measured. The contents of nitric oxide (NO) and nitric oxide synthase (NOS) in blood were measured by spectrophotometer. The number of patients with adverse reactions was counted. Results after treatment, the TG,TC and LDC-C values of the experimental group showed a downward trend, while the HDL-C value showed an increasing trend, compared with the control group, the difference was statistically significant (P0.05), while that of simvastatin group and pravastatin group was significantly higher than that of the control group (P0.05). There was no significant difference in Atto vastatin group (P0.05). The effective rate of treatment in the experimental group was as high as 70.08, compared with the control group, the difference was statistically significant (P0.05). The IMT and the maximum diameter of plaque in the experimental group were significantly different from those before treatment (P0.05), but there was no significant difference between each group (P0.05). The levels of NO and NOS in the experimental group were significantly higher than those before treatment and in the control group (P0.05). The levels of NO and NOS in the experimental group were higher than those in the control group. Follow-up results showed that statins were safe and effective during use. Conclusion statins are safe, effective and reliable in the treatment of atherosclerosis, and can effectively regulate the content of NO,NOS in the blood of patients.
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本文编号：2358464
[Abstract]:Objective to investigate the effect of statins on atherosclerosis and its mechanism. Methods 104 patients with atherosclerosis were randomly divided into control group, simvastatin group, pravastatin group and Atto vastatin group. The levels of triglyceride (TG), total cholesterol (TC), high density lipoprotein cholesterol (HDL-C) and low density lipoprotein cholesterol (LDC-C) were measured before and 6 months after treatment in the four groups. At the same time, the thickness of intima-media, the maximum diameter and thickness of atherosclerotic plaques were measured. The contents of nitric oxide (NO) and nitric oxide synthase (NOS) in blood were measured by spectrophotometer. The number of patients with adverse reactions was counted. Results after treatment, the TG,TC and LDC-C values of the experimental group showed a downward trend, while the HDL-C value showed an increasing trend, compared with the control group, the difference was statistically significant (P0.05), while that of simvastatin group and pravastatin group was significantly higher than that of the control group (P0.05). There was no significant difference in Atto vastatin group (P0.05). The effective rate of treatment in the experimental group was as high as 70.08, compared with the control group, the difference was statistically significant (P0.05). The IMT and the maximum diameter of plaque in the experimental group were significantly different from those before treatment (P0.05), but there was no significant difference between each group (P0.05). The levels of NO and NOS in the experimental group were significantly higher than those before treatment and in the control group (P0.05). The levels of NO and NOS in the experimental group were higher than those in the control group. Follow-up results showed that statins were safe and effective during use. Conclusion statins are safe, effective and reliable in the treatment of atherosclerosis, and can effectively regulate the content of NO,NOS in the blood of patients.
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本文编号：2358464
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