人附睾蛋白4对急性心力衰竭患者预后的预测价值

发布时间：2018-12-09 09:42

【摘要】：探讨人附睾蛋白4(HE4)对急性心力衰竭患者预后的预测价值。入组2015年1月~2016年2月住院的急性心力衰竭患者178例,检测患者血清中HE4的表达水平,并对患者进行随访,记录患者死亡和再住院情况。HE4在心力衰竭组明显高于健康对照组[(7.8±0.6)ng/ml vs.(2.2±0.5)ng/ml,P0.05)],且随心功能分级的恶化,HE4水平明显升高[(5.3±0.4)ng/ml vs.(7.6±0.5)ng/ml vs.(9.7±0.6)ng/ml,P0.05)],多因素Cox生存分析表明:HE4是预测急性心力衰竭患者预后的独立预测指标(χ2=10.26,HR95%CI:2.25(0.67~4.14),P0.001),进一步分析显示:HE47.5ng/ml的患者死亡和再入院的风险是HE4≤7.5ng/ml的患者的7.12倍。HE4能够反映急性心力衰竭的严重程度,并且能够预测急性心力衰竭患者的预后。
[Abstract]:To investigate the prognostic value of human epididymal protein 4 (HE4) in patients with acute heart failure. From January 2015 to February 2016, 178 patients with acute heart failure were enrolled in the study. The expression of HE4 in serum was detected, and the patients were followed up. HE4 in heart failure group was significantly higher than that in healthy control group [(7.8 卤0.6) ng/ml vs. (2.2 卤0.5) ng/ml,P0.05], and it deteriorated with cardiac function grade. The level of HE4 was significantly increased [(5.3 卤0.4) ng/ml vs. (7.6 卤0.5) ng/ml vs. (9.7 卤0.6) ng/ml,P0.05]. Multivariate Cox survival analysis showed that HE4 was an independent predictor of prognosis in patients with acute heart failure (蠂 2 / 10.26 / HR95 CI: 2.25 (0.674.14), P0.001). Further analysis showed that the risk of death and readmission in patients with HE47.5ng/ml was 7.12 times higher than that in patients with HE4 鈮，

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