识别与蛋白C及脂蛋白代谢相关的遗传变异性:社区动脉粥样硬化风险研究
发布时间：2018-12-19 16:28
【摘要】：正先前研究已经确定占蛋白C循环水平变化14%~15%的4个染色体区域常见遗传变异。为了进一步了解蛋白C的遗传架构,研究人员在一些基因位点进行更密集广泛的研究,进一步调查蛋白C的低频率罕见变异,探寻影响蛋白C基因的新的相关性。方法与结果:纳入年龄45~64岁的白人10 778和非洲裔3190人,评估遗传与蛋白C抗原水平的相关性。用Illumina ITMAT-Broad-CARe芯片和Illumina人类外显子珠芯片对其他低频和罕见变异进行直接基因分型。研
[Abstract]:Previous studies have identified common genetic variations in four chromosomal regions accounting for 14% of the changes in protein C cycle levels. In order to further understand the genetic structure of protein C, researchers carried out more intensive and extensive studies at some gene sites, further investigated the low frequency rare variation of protein C, and explored the new correlation affecting protein C gene. Methods and results: a total of 10 778 white people aged 45 to 64 years old and 3190 people of African descent were included to evaluate the correlation between heredity and protein C antigen level. Other low frequency and rare mutations were genotyped by Illumina ITMAT-Broad-CARe microarray and Illumina human exon bead chip. Research
【分类号】：R543.5
本文编号：2387172
[Abstract]:Previous studies have identified common genetic variations in four chromosomal regions accounting for 14% of the changes in protein C cycle levels. In order to further understand the genetic structure of protein C, researchers carried out more intensive and extensive studies at some gene sites, further investigated the low frequency rare variation of protein C, and explored the new correlation affecting protein C gene. Methods and results: a total of 10 778 white people aged 45 to 64 years old and 3190 people of African descent were included to evaluate the correlation between heredity and protein C antigen level. Other low frequency and rare mutations were genotyped by Illumina ITMAT-Broad-CARe microarray and Illumina human exon bead chip. Research
【分类号】：R543.5
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