达比加群酯对心房颤动射频消融患者抗凝治疗中的临床疗效

发布时间：2019-01-05 06:25

【摘要】：目的：通过回顾分析研究达比加群酯与华法林对心房颤动射频消融患者抗凝治疗中的临床疗效。方法：研究对象选自2012年1月-2015年1月吉林大学第一附属医院心内科收治行导管射频消融治疗的房颤患者107例。收集所有患者的年龄、性别、肝功、肾功等基本指标。所有患者均经过纳入排除标准筛选，，于围手术期应用华法林亦或是达比加群酯行抗凝治疗。对患者进行1年随访，以血栓性终点与安全性终点为研究终点，对比两组患者的临床疗效和出血风险。结果: 1、达比加群酯观察组血栓栓塞事件的发生率为3.2%(1/31)，华法林对照组血栓栓塞事件的发生率为3.9%(3/76)，两组差异不拘有统计学意义(P＞0.05）。华法林导致缺血性脑卒中病例的INR未达标。 2、达比加群酯观察组出血并发症的发生率为6.5%(2/31)，华法林对照组出血并发症的发生率为9.2%(5/76)；两组差异不具有统计学意义(P＞0.05）。两组均未见严重出血并发症。结论： 1、心房颤动射频消融采用达比加群酯抗凝治疗疗效确切，不劣于华法林抗凝治疗。 2、心房颤动射频消融采用达比加群酯抗凝治疗与华法林抗凝治疗的出血风险相当，免于INR检测。
[Abstract]:Objective: to study the clinical effect of radiofrequency ablation of atrial fibrillation (AF) with dabiganate and warfarin. Methods: 107 patients with atrial fibrillation treated by radiofrequency catheter ablation were selected from January 2012 to January 2015 in Cardiology Department of the first affiliated Hospital of Jilin University. The age, sex, liver function and kidney function of all patients were collected. All patients were screened by exclusion criteria for anticoagulant therapy with warfarin or dacitrate during perioperative period. The patients were followed up for 1 year. Thrombotic endpoints and safety endpoints were used as the study endpoints to compare the clinical efficacy and bleeding risk between the two groups. Results: 1. The incidence of thromboembolism was 3.2% (1 / 31) in the Darby plus group and 3.9% (3 / 76) in the warfarin control group. The difference between the two groups was statistically significant (P > 0.05). Warfarin leads to INR substandard in ischemic stroke cases. 2. The incidence of bleeding complications in the observation group was 6.5% (2 / 31), and that in the warfarin control group was 9.2% (5 / 76), there was no significant difference between the two groups (P > 0.05). No severe bleeding complications were found in both groups. Conclusion: 1. Radiofrequency catheter ablation of atrial fibrillation is effective in treating atrial fibrillation with dapib plus group ester, and is not inferior to warfarin anticoagulant therapy. 2, radiofrequency ablation of atrial fibrillation with dapib plus group ester anticoagulant therapy had the same risk of bleeding as warfarin anticoagulant therapy, and was exempt from INR detection.
【学位授予单位】：吉林大学
【学位级别】：硕士
【学位授予年份】：2015
【分类号】：R541.75

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