马来酸依那普利叶酸片治疗老年慢性心力衰竭临床疗效观察

发布时间：2019-01-12 10:56

【摘要】：目的探讨老年慢性心力衰竭患者接受马来酸依那普利叶酸片治疗后氨基末端B型脑钠肽前体(NT-pro BNP)及同型半胱氨酸(Hcy)水平变化及其意义。方法选取该院110例老年急性左心衰竭患者为研究对象,按照随机数表法将患者分为对照组和观察组,每组各55例,同时选取同期于该院检查的健康老年患者55例为健康组。在常规治疗基础上,对照组予以依那普利治疗,观察组予以马来酸依那普利叶酸片治疗,健康组予以安慰剂。分别测定治疗前后各组NT-pro BNP及Hcy水平并分析其临床意义。结果老年慢性心力衰竭患者NT-pro BNP及Hcy水平明显高于健康组(P0.05);随着心功能分级增加,其值越高(P0.05)。观察组治疗24周后NT-pro BNP及Hcy水平明显低于对照组(P0.05)。且观察组患者心脏结构参数与心功能分级均较治疗前有显著改善(P0.05),优于对照组患者(P0.05)。结论马来酸依那普利叶酸片可有效降低老年慢性心力衰竭患者NT-pro BNP及Hcy水平,改善患者预后。
[Abstract]:Objective to investigate the changes of amino-terminal brain natriuretic peptide precursor (NT-pro BNP) and homocysteine (Hcy) in elderly patients with chronic heart failure treated with enalapril maleate folic acid tablets. Methods 110 elderly patients with acute left ventricular failure were selected and divided into control group and observation group according to random number method. 55 healthy elderly patients who were examined in the same period were selected as healthy group. On the basis of routine treatment, the control group was treated with enalapril, the observation group with enalapril maleate folic acid tablets and the healthy group with placebo. The levels of NT-pro BNP and Hcy were measured before and after treatment and their clinical significance was analyzed. Results the levels of NT-pro BNP and Hcy in elderly patients with chronic heart failure were significantly higher than those in healthy controls (P0.05), and the higher the cardiac function grade was (P0.05). The levels of NT-pro BNP and Hcy in the observation group were significantly lower than those in the control group after 24 weeks of treatment (P0.05). The parameters of heart structure and cardiac function in the observation group were significantly improved compared with those before treatment (P0.05), which was better than that in the control group (P0.05). Conclusion Enalapril maleate folate tablets can effectively reduce the levels of NT-pro BNP and Hcy and improve the prognosis of elderly patients with chronic heart failure.
【作者单位】：河南省中医院重症医学科;
【分类号】：R541.6

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