麝香保心丸治疗冠心病心绞痛患者的疗效观察及对远期心脏事件的影响

发布时间：2019-02-13 11:24

【摘要】：目的:观察麝香保心丸对冠心病心绞痛患者的疗效及对远期心脏事件的影响。方法:所选患者为我院门诊或住院的冠心病心绞痛患者120例,随机选择对照组60例,给予常规冠心病二级预防治疗(如阿司匹林、他汀类、β受体阻滞剂、血管紧张素转换酶抑制剂等),随机选择同期观察组60例,观察组患者在常规治疗基础上口服麝香保心丸2粒/次,3次/日,观察18个月。结果:观察组与对照组治疗18个月后比较血生化指标,如TC、TG、LDL-C、纤维蛋白原、血粘度、心肌总缺血负荷及心脏相关事件(心绞痛发作次数、硝酸甘油消耗量、因心绞痛再住院率、心梗、心源性休克及猝死等)等均具有统计学意义(P0.05)。结论:麝香保心丸可有效降低冠心病心绞痛患者血液中TG、TC、LDL-C、纤维蛋白原及血粘度,还可降低患者的心肌细胞所有缺血的负荷,减少了冠心病心绞痛患者远期(18个月)心脏相关事件的发生。
[Abstract]:Objective: to observe the effect of Shexiang Baoxin Pill on angina pectoris and long-term cardiac events. Methods: 120 patients with angina pectoris of coronary heart disease were selected in our hospital, and 60 patients in control group were randomly selected and treated with routine secondary prophylaxis of coronary heart disease (such as aspirin, statins, 尾 receptor blockers). Angiotensin converting enzyme inhibitor (angiotensin converting enzyme inhibitor etc.), 60 patients in the observation group were randomly selected. The patients in the observation group were given 2 tablets of Shexiang Baoxin pills on the basis of routine treatment, 3 times a day for 18 months. Results: the blood biochemical indexes such as TC,TG,LDL-C, fibrinogen, blood viscosity, total myocardial ischemic load and cardiac events (angina pectoris attack, nitroglycerin consumption) were compared between the observation group and the control group after 18 months of treatment. The readmission rate of angina pectoris, myocardial infarction, cardiogenic shock and sudden death were statistically significant (P0.05). Conclusion: Shexiang Baoxin pills can effectively reduce the TG,TC,LDL-C, fibrinogen and blood viscosity in patients with angina pectoris, and can also reduce the load of all myocardial ischemia in patients with angina pectoris. Decreased long-term (18 months) incidence of heart-related events in patients with coronary heart disease and angina pectoris.
【学位授予单位】：山西医科大学
【学位级别】：硕士
【学位授予年份】：2015
【分类号】：R541.4

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