重组脑钠肽治疗顽固性心力衰竭的疗效及对血流动力学、心功能的影响

发布时间：2019-02-28 17:20

【摘要】：目的探讨重组脑钠肽(rh BNP)治疗顽固性心力衰竭的疗效及对血流动力学、心功能的影响。方法顽固性心力衰竭患者56例,回顾性分析其治疗方法及实验室检查结果,分为接受常规治疗的对照组29例、接受常规治疗+rh BNP治疗的观察组27例。评估两组治疗效果;采用Swan-Ganz漂浮导管测定血流动力学参数水平;应用彩色多普勒超声仪测定心功能参数水平。结果治疗前,两组血流动力学参数、心功能参数水平差异无统计学意义(P0.05)。治疗1 w后,观察组治疗总有效率高于对照组(P0.05);观察组血流动力学指标中心静脉压(CVP)、右房压(RAP)、肺毛细血管楔压(PCWP)水平低于对照组(P0.05);观察组心功能参数左室收缩末期内径(LVESD)、左室舒张压末期内径(LVEDD)水平低于对照组,左室射血分数(LVEF)水平高于对照组(P0.05)。结论 rh BNP可改善顽固性心力衰竭患者心功能、优化血流动力学状态。
[Abstract]:Objective to evaluate the efficacy of recombinant brain natriuretic peptide (rh BNP) in the treatment of refractory heart failure (CHF) and its effects on hemodynamics and cardiac function. Methods 56 patients with refractory heart failure were divided into control group (n = 29) and rh BNP group (n = 27). The hemodynamic parameters were measured by Swan-Ganz floating catheter, and the cardiac function parameters were measured by color Doppler ultrasound (CDFI). Results before treatment, there was no significant difference in hemodynamic parameters and cardiac function parameters between the two groups (P0.05). After 1 week treatment, the total effective rate in the observation group was higher than that in the control group (P0.05), and the (PCWP) level of the right atrial pressure (CVP), in the observation group was lower than that in the control group (P0.05). The left ventricular end-systolic diameter (LVESD),) and left ventricular end-diastolic pressure (LVEDD) (LVEDD) level were lower and the left ventricular ejection fraction (LVEF) level was higher in the observation group than in the control group (P0.05). Conclusion rh BNP can improve cardiac function and optimize hemodynamics in patients with refractory heart failure.
【作者单位】：佛山市第一人民医院心内科;
【分类号】：R541.6

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