内皮唾液酸蛋白通过调节血管平滑肌细胞表型重建,促进动脉粥样硬化
发布时间：2019-03-11 13:22
【摘要】：正动脉粥样硬化是全球主要的致死原因,血管平滑肌细胞(vascular smooth muscle cells,VSMC)在动脉粥样硬化的发病中起关键作用。内皮唾液酸蛋白(CD248)已被认为是间质细胞系细胞(包括肿瘤相关周细胞、肌成纤维细胞间质和活化的VSMC)的激活标记物。因此,研究人员假设VSMC表达的内皮唾液酸蛋白可以功能性地参与动脉粥样硬化的发病。方法与结果:通过定量逆转录聚合酶链反应和免疫组化分
[Abstract]:Positive atherosclerosis is the leading cause of death in the world. Vascular smooth muscle cells (vascular smooth muscle cells,VSMC) play a key role in the pathogenesis of atherosclerosis. Endothelial sialic acid protein (CD248) has been considered to be an activation marker for stromal cell lines including tumor-associated pericytes, myofibroblast stroma and activated VSMC. Therefore, the researchers hypothesized that VSMC-expressed endothelial sialic acid protein could functionally participate in the pathogenesis of atherosclerosis. Methods and results: quantitative reverse transcription polymerase chain reaction (QRT-PCR) and immunohistochemical staining were performed.
【分类号】：R543.5
，
本文编号：2438313
[Abstract]:Positive atherosclerosis is the leading cause of death in the world. Vascular smooth muscle cells (vascular smooth muscle cells,VSMC) play a key role in the pathogenesis of atherosclerosis. Endothelial sialic acid protein (CD248) has been considered to be an activation marker for stromal cell lines including tumor-associated pericytes, myofibroblast stroma and activated VSMC. Therefore, the researchers hypothesized that VSMC-expressed endothelial sialic acid protein could functionally participate in the pathogenesis of atherosclerosis. Methods and results: quantitative reverse transcription polymerase chain reaction (QRT-PCR) and immunohistochemical staining were performed.
【分类号】：R543.5
，
本文编号：2438313
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