氨氯地平联合依那普利对老年高血压患者血管内皮功能及血清IL-12、TNF-α、hs-CRP水平的影响

发布时间：2019-03-11 20:32

【摘要】：目的探讨氨氯地平、依那普利联合治疗对老年高血压患者血管内皮功能、血清超敏C反应蛋白(hs-CRP)、肿瘤坏死因子(TNF)-α、白细胞介素(IL)-12水平及血压变异性的影响。方法老年高血压患者162例随机数字表法分为对照组、观察组各81例。对照组采用氨氯地平治疗,观察组采用依那普利+氨氯地平治疗,两组均持续治疗1个月。治疗后对比两组疗效、不良反应、血压变化情况及血管内皮功能指标[血浆一氧化氮(NO)、内皮素(ET)-1]、血清IL-12、TNF-α、hs-CRP水平。结果治疗前两组24 h收缩压(SBP)、24 h舒缩压(DBP)、24 h SBP变异性(SBPV)、24 h DBP变异性(DBPV)差异无统计学意义(P0.05);治疗后,观察组24 h SBP、24 h DBP、24 h SBPV、24 h DBPV均较对照组显著降低(P0.05)。观察组总有效率[97.53%(79/81)]较对照组[80.25%(65/81)]显著升高,不良反应发生率(1.23%)较对照组(12.35%)显著降低(P0.05)。治疗后观察组内皮功能指标较治疗前显著改善,且优于对照组(P0.05)。与对照组相比,观察组治疗后血清TNF-α、IL-12、hs-CRP均显著降低(P0.05)。结论老年高血压患者采用氨氯地平、依那普利联合治疗能有效提高血压控制效果,显著改善血管内皮功能。
[Abstract]:Objective to investigate the effects of amlodipine and enalapril on vascular endothelial function, serum hypersensitive C-reactive protein (hs-CRP) and tumor necrosis factor-伪 (TNF)-伪) in elderly patients with hypertension. Effects of interleukin-12 (IL-12) and blood pressure variability (BP) on (IL)-12 levels. Methods 162 elderly patients with hypertension were randomly divided into control group (n = 81) and observation group (n = 81). The patients in the control group were treated with amlodipine and the patients in the observation group were treated with enalapril amlodipine. After treatment, the therapeutic effects, adverse reactions, blood pressure changes and vascular endothelial function indexes [plasma nitric oxide (NO), endothelin (ET)-1], serum IL-12,TNF- 伪, hs-CRP levels were compared between the two groups. Results 24 h systolic blood pressure (SBP), 24 h diastolic blood pressure (DBP), 24 h SBP variability (SBPV), 24 h DBP variability (DBPV) had no significant difference between the two groups before treatment (P0.05). After treatment, the 24 h SBP,24 / h DBP,24 / h SBPV,24 / h DBPV in the observation group was significantly lower than that in the control group (P0.05). The total effective rate of the observation group [97.53% (79 / 81)] was significantly higher than that of the control group [80.25% (65 / 81)], and the incidence of adverse reactions (1.23%) was significantly lower than that of the control group (12.35%) (P0.05). After treatment, the endothelial function in the observation group was significantly improved compared with that before treatment, and was better than that in the control group (P0.05). Compared with the control group, the serum TNF- 伪 and IL-12,hs-CRP were significantly lower in the observation group after treatment (P0.05). Conclusion Amlodipine and enalapril combined with amlodipine and enalapril can effectively improve blood pressure control and vascular endothelial function in elderly patients with hypertension.
【作者单位】：天津市第五中心医院药剂科;天津市第五中心医院心内科;
【分类号】：R544.1

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