腰臀比纵向轨迹与动脉硬化的关联性

发布时间：2019-03-12 15:02

【摘要】：目的探讨腰臀比纵向轨迹与动脉硬化的关联。方法研究队列由开滦卒中队列、老年人群队列、妊娠队列和外周血管疾病筛查队列组成,其中符合入选标准的研究对象共9080名。通过SAS Proc Traj程序确定观察对象2006-2007、2008-2009、2010-2011年健康体检的腰臀比纵向轨迹,生成4组不同的腰臀比轨迹组:低-中轨迹组、中-稳定轨迹组、高-高轨迹组、高-中轨迹组,并于2010-2015年对观察对象进行了肱踝动脉脉搏波传导速度(baPWV)检测。采用协方差分析校正了年龄、性别后不同腰臀比纵向轨迹分组baPWV的差异。采用多因素Logistic回归模型分析腰臀比纵向轨迹与动脉硬化的关联。定义baPWV≥1400cm/s为动脉硬化。结果与其他腰臀比轨迹组相比,高-高轨迹组的baPWV值[(1545.56±4.31)cm/s]、动脉硬化人群比例(67.5%)均最高。低-中轨迹组、中-稳定轨迹组、高-高轨迹组、高-中轨迹组动脉硬化的发生率分别为:28.8%、50.0%、67.5%、55.4%。在多因素Logistic回归分析中,校正了其他混杂因素后,与低-中轨迹组相比,中-稳定轨迹组、高-高轨迹组、高-中轨迹组是动脉硬化发生的危险因素,对应的OR值(95%CI)分别为1.42(1.15~1.76)、1.80(1.42~2.29)、1.63(1.11~2.38),均P0.05。此外,分别除外服用降压药、降糖药、降脂药人群后进行了敏感性分析,结果与主要研究结果趋势一致。结论腰臀比纵向轨迹水平升高是发生动脉硬化的危险因素。
[Abstract]:Objective to investigate the relationship between waist hip ratio longitudinal trajectory and arteriosclerosis. Methods the study cohort consisted of Kailuan stroke cohort, elderly population cohort, pregnancy cohort and peripheral vascular disease screening cohort. The longitudinal trajectory of waist-to-hip ratio was determined by SAS Proc Traj program in 2006 / 2007, 2008 / 2009, 2010-2011, and four different WHR trackgroups were generated: low-middle trackgroup, middle-stable trackgroup, high-high trackgroup, high-middle trackgroup, low-middle trackgroup, high-middle trackgroup. The pulse wave velocity (baPWV) of brachial-malleolar artery was measured from 2010 to 2015. Covariance analysis was used to correct the difference of baPWV between different waist-hip ratio longitudinal trajectory groups after age and sex. Multi-factor Logistic regression model was used to analyze the relationship between waist-hip ratio longitudinal trajectory and arteriosclerosis. BaPWV 鈮，

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