原发性高血压患者血清胱抑素C与臂踝动脉脉搏波传导速度的相关性

发布时间：2019-03-17 21:39

【摘要】：目的探讨原发性高血压患者血清胱抑素C与臂踝动脉脉搏波传导速度(baPWV)的相关性。方法选取2014年5月至2015年10月山西医科大学第一医院高血压病区的原发性高血压患者234(男131、女103)例,年龄(56.5±12.0)岁。按血压水平将患者分为高血压1级、2级、3级组,另选取健康体检者187名作为对照组。检测baPWV、踝臂血压指数(ABI)、血清胱抑素C、血肌酐、空腹血糖、血脂及尿微量白蛋白水平;采用多元线性回归分析baPWV与胱抑素C的相关性。结果高血压1级、2级、3级组的baPWV高于对照组[(16.65±3.41)、(18.37±3.51)、(18.53±4.18)比(15.48±2.68)m/s,均P0.05],高血压2级、3级组高于1级组(P0.01)。高血压1级、2级、3级组血清胱抑素C高于对照组[(0.80±0.21)、(0.86±0.30)、(1.15±0.32)比(0.56±0.25)mg/L,均P0.05],高血压3级高于1级、2级组(均P0.05)。Pearson相关分析结果显示,baPWV与血清胱抑素C、年龄、收缩压、舒张压、心率、血糖呈正相关(分别r=0.357、0.605、0.479、0.184、0.227、0.150,均P0.05),与BMI呈负相关(r=-0.235,P0.01)。多元线性回归分析中校正各混杂因素后,发现胱抑素C仍是baPWV的影响因素(B=291.970,P0.01)。结论原发性高血压患者血清胱抑素C与baPWV呈正相关。
[Abstract]:Objective to investigate the relationship between serum cystatin C and brachial and malleolus artery pulse wave velocity (baPWV) in patients with essential hypertension. Methods from May 2014 to October 2015, 234 patients with essential hypertension (male 131, female 103), aged (56.5 卤12.0) years old, were selected from the hypertension area of the first Hospital of Shanxi Medical University. According to the level of blood pressure, the patients were divided into three groups: grade 1, grade 2 and grade 3. 187 healthy subjects were selected as control group. The levels of serum cystatin C, serum creatinine, fasting blood glucose, blood lipid and urinary microalbumin were measured in baPWV, ankle-brachial blood pressure index (ABI), and the correlation between baPWV and cystine C was analyzed by multiple linear regression. Results the baPWV of grade 1, grade 2 and grade 3 hypertension was higher than that of control group [(16.65 卤3.41), (18.37 卤3.51), (18.53 卤4.18) vs (15.48 卤2.68) mm2, P 0.05]. The level 3 group was higher than grade 1 group (P0.01). The level of serum cystatin C in grade 1, grade 2 and grade 3 hypertension was significantly higher than that in control group [(0.80 卤0.21), (0.86 卤0.30), (1.15 卤0.32) vs (0.56 卤0.25) mg/L, P 0.05], and grade 3 was higher than grade 1. Pearson correlation analysis showed that baPWV was positively correlated with serum cystatin C, age, systolic blood pressure, diastolic blood pressure, heart rate and blood glucose (r = 0.357, 0.605,0.479, 0.184, 0.227, 0.150, P 0.05, respectively). There was a negative correlation with BMI (r = 0.235, P0.01). After adjusting the confounding factors in multivariate linear regression analysis, it was found that cystatin C was still the influencing factor of baPWV (B = 291.970, P0.01). Conclusion Serum cystatin C is positively correlated with baPWV in patients with essential hypertension.
【作者单位】：武警陕西省总队医院干部病房;山西医科大学第一医院高血压科;
【分类号】：R544.11

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