冠状动脉慢血流患者的影响因素分析

发布时间：2019-04-15 20:16

【摘要】：目的:探讨冠状动脉造影慢血流患者的影响因素。方法:回顾性分析2008-01至2010-09于滨州医学院附属医院行冠状动脉造影检查的1 530例患者中的冠状动脉造影结果,入选患者根据校正的心肌梗死溶栓治疗临床试验(TIMI)后血流计帧数筛选出冠状动脉无明显狭窄但冠状动脉血流缓慢者139例为试验组,同期冠状动脉无明显狭窄且血流正常的患者232例作为对照组。统计常规临床实验室指标,比较两组患者的一般情况、实验室检查指标的差异、危险因素,并通过多因素Logistic回归分析冠状动脉慢血流的临床影响因素。结果:(1)两组患者比较,年龄、性别、吸烟史、糖尿病病史、红细胞、血红蛋白、平均红细胞血红蛋白浓度、红细胞压积、中性粒细胞、单核细胞、嗜碱性粒细胞、淋巴细胞/单核细胞、中性粒细胞/单核细胞、平均红细胞体积、红细胞分布宽度SD、中性粒细胞/淋巴细胞、血小板/淋巴细胞、谷草转氨酶、肌酸激酶及总胆汁酸差异均有统计学意义(P0.05)。(2)相关分析显示,红细胞(r=0.191,P0.01)、血红蛋白(r=0.184,P0.01)、中性粒细胞(r=0.218,P0.01)、平均红细胞血红蛋白浓度(r=0.151,P0.01)、平均红细胞体积(r=-0.138,P0.01)、总胆汁酸(r=-0.172,P0.01)、中性粒细胞/淋巴细胞(r=0.231,P0.01)、淋巴细胞/单核细胞(r=-0.157,P0.01)、中性粒细胞/单核细胞(r=0.121,P0.01)与三支平均血流帧数显著相关。(3)多因素Logistic回归分析显示,总胆汁酸(偏回归系数=-0.102,P0.01)、淋巴细胞/单核细胞(偏回归系数=-0.381,P0.01)、中性粒细胞/单核细胞(偏回归系数=0.489,P0.01)是冠状动脉慢血流的独立影响因素。结论:总胆汁酸、淋巴细胞/单核细胞、中性粒细胞/单核细胞是冠状动脉慢血流的影响因素。
[Abstract]:Objective: to investigate the influencing factors of slow blood flow in coronary angiography. Methods: the results of coronary angiography were retrospectively analyzed in 1 530 patients who underwent coronary angiography from January 2008 to September 2010 in the affiliated Hospital of Binzhou Medical College. According to the frame number of blood flow meter after the corrected thrombolytic therapy of myocardial infarction (TIMI), a total of 139 patients with no significant coronary artery stenosis but slow coronary flow were selected as the experimental group. In the same period, 232 patients with no obvious coronary artery stenosis and normal blood flow were served as control group. Statistics of routine clinical laboratory indexes, comparison of the general conditions of the two groups, the differences of laboratory parameters, risk factors, and multi-factor Logistic regression analysis of the clinical factors of coronary artery slow blood flow. Results: (1) the age, sex, smoking history, history of diabetes, red blood cells, hemoglobin, mean hemoglobin concentration, hematocrit, neutrophils, monocytes and basophils were compared between the two groups. Lymphocytes / monocytes, neutrophils / monocytes, mean red blood cell volume, red blood cell distribution width SD, neutrophil / lymphocyte, platelet / lymphocyte, glutamic oxaloacetic transaminase, The differences of creatine kinase and total bile acid were statistically significant (P0.05). (2). The correlation analysis showed that red blood cells (r = 0.191, P0.01), hemoglobin (r = 0.184, P0.01), neutrophils (r = 0.218, P0.01), and neutrophils (r = 0.218, P0.01). Mean hemoglobin concentration (r = 0.151, P0.01), mean red cell volume (r = 0.138, P0.01), total bile acid (r = 0.172, P0.01), neutrophil / lymphocyte (r = 0.231, P0.01), mean erythrocyte hemoglobin concentration (r = 0.151, P0.01), mean red blood cell volume (r = 0.138, P0.01), total bile acid (r = 0.172, P0.01), Lymphocyte / monocyte (r = 0.157, P 0.01), neutrophil / monocyte (r = 0.121, P 0.01) were significantly correlated with the mean number of three blood flow frames. (3) Multivariate Logistic regression analysis showed that there was a significant correlation between the number of monocytes and lymphocytes / monocytes (r = 0.121, P 0.01). Total bile acid (partial regression coefficient =-0.102, P0.01), lymphocyte / monocyte (partial regression coefficient =-0.381, P0.01), neutrophil / monocyte (partial regression coefficient = 0.489, P < 0.01). P01) is an independent influencing factor of coronary slow blood flow. Conclusion: total bile acid, lymphocyte / monocyte, neutrophil / monocyte are the influencing factors of coronary artery slow blood flow.
【作者单位】：滨州医学院附属医院老年医学科;
【基金】：山东省科技发展计划医药卫生项目(2013TD18019) 山东省医药卫生科技计划(2015BJYB31) 滨州市科技发展计划(2015ZC0315)
【分类号】：R54

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