超声心动图评价心力衰竭模型大鼠心功能及其与血清B型钠尿肽的关系

发布时间：2019-05-06 17:10

【摘要】：目的探讨超声心动图评价心力衰竭模型大鼠心功能及其与大鼠血清B型钠尿肽(BNP)的关系。方法将80只雄性SD大鼠随机分为手术组(50只)与正常对照组(30只),手术组行左冠状动脉前降支结扎术进行心力衰竭造模,正常对照组不给予任何手术处理,术前及术后50 d记录大鼠体重变化;在术后50 d采用超声心动仪对大鼠心脏的左室舒张末期内径(LVIDd)、左室收缩末期内径(LVIDs)、左室后壁厚度(LVPW)及室间隔厚度(IVS)进行测量,计算左室射血分数(LVEF)和左室内径缩短率(LVFS),测定大鼠血清BNP含量,比较心功能改变与大鼠血清BNP含量的相关性。结果手术组与正常对照组大鼠心功能相比,LVIDd、LVIDs显著增高,LVPW、IVS、LVEF、LVFS均显著下降,血清BNP含量明显增高(均P0.05)。Pearson相关性分析显示,大鼠血清BNP含量与LVPW、IVS、LVEF、LVFS呈负相关(P0.05),与LVIDd、LVIDs呈正相关(P0.05)。结论超声心动图对心力衰竭大鼠的心功能改变评价结果良好,且心功能的改变与大鼠血清BNP含量存在相关性。
[Abstract]:Objective to evaluate the relationship between heart function and serum B-type natriuretic peptide (BNP) in rats with heart failure by echocardiography. Methods 80 male SD rats were randomly divided into two groups: operation group (n = 50) and normal control group (n = 30). The model of heart failure was made by ligation of left anterior descending branch of coronary artery in the operation group, and no surgical treatment was given to the normal control group. The weight changes of rats were recorded before and 50 days after operation. The left ventricular end diastolic diameter (LVIDd), left ventricular end systolic diameter (LVIDs), left ventricular posterior wall thickness (LVPW) and interventricular septum thickness (IVS) were measured by echocardiography on the 50th day after operation. The left ventricular ejection fraction (LVEF) and left ventricular diameter shortening rate (LVFS),) were calculated to determine the serum BNP content in rats. The correlation between the changes of cardiac function and the serum BNP content in rats was compared. Results compared with normal control group, LVIDd,LVIDs increased significantly, LVPW,IVS,LVEF,LVFS decreased significantly and serum BNP increased significantly in the operation group (P0.05). Pearson correlation analysis showed that the serum BNP content and LVPW,IVS, in the rats were significantly higher than those in the control group (P < 0.05). LVEF,LVFS was negatively correlated (P0.05) and positively correlated with LVIDd,LVIDs (P0.05). Conclusion Echocardiography has good results in evaluating the changes of heart function in rats with heart failure, and there is a correlation between the changes of heart function and the content of serum BNP in rats.
【作者单位】：天津中医药大学第一附属医院功能检查科;
【分类号】：R-332;R541.6

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