冠心病患者血清中趋化因子CXC配体5的表达及其临床意义

发布时间：2019-05-09 04:28

【摘要】：目的研究不同临床类型冠心病(CHD)患者和正常人血清中趋化因子CXC配体(L)5蛋白的表达差异。方法酶联免疫吸附法检测59例CHD患者和23例正常人血清中CXCL5蛋白的表达。结果正常对照组、稳定型心绞痛(SAP)组、不稳定型心绞痛(UAP)组和急性心肌梗死(AMI)组血清中的CXCL5蛋白水平分别为(63.47±5.67)、(64.37±7.26)、(69.74±7.99)和(70.84±9.44)ng/ml,与正常对照组和SAP组比较,UAP组和AMI组显著增高(P0.05);与血清CXCL5水平60 ng/ml组比较,CHD组血清CXCL5水平70 ng/ml组Gensini评分显著增高(P0.05)。结论血清CXCL5水平与CHD病情具有相关性,其可能作用一个经典的炎症因子参与CHD进程。检测血清CXCL5的水平和针对CXCL5相关治疗可为CHD的临床诊断和治疗提供新的标志物和靶点。
[Abstract]:Objective to study the expression of chemokine CXC ligand (L) 5 protein in serum of patients with different clinical types of coronary heart disease (CHD) and normal controls. Methods enzyme-linked immunosorbent assay (Elisa) was used to detect the expression of CXCL5 protein in serum of 59 patients with CHD and 23 normal subjects. Results the serum CXCL5 protein levels in normal control group, stable angina pectoris (SAP) group, unstable angina pectoris (UAP) group and acute myocardial infarction (AMI) group were 63.47 卤5.67), (64.37 卤7.26, respectively. (6974 卤7.99) and (70.84 卤9.44) ng/ml, were significantly higher in UAP group and AMI group than those in normal control group and SAP group (P 0.05). Compared with the serum CXCL5 level of 60 ng/ml group, the serum CXCL5 level of the CHD group was significantly higher than that of the 70 ng/ml group (P0.05). Conclusion the level of serum CXCL5 is correlated with the condition of CHD, and it may play a role in the process of CHD by a classical inflammatory factor. Detection of serum CXCL5 level and CXCL5-related therapy can provide new markers and targets for clinical diagnosis and treatment of CHD.
【作者单位】：佳木斯市中心医院心内科;
【分类号】：R541.4

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