餐后低血压与服用降压药时间的关系

发布时间：2019-05-27 14:16

【摘要】：目的:观察原发性高血压患者进食早餐后血压变化的规律;探讨餐后低血压与服用降压药时间的关系。方法:选取住院的原发性高血压患者54例,其中男患者30例,女患者24例,平均年龄为58.9±11.1岁,平均病程为6.9±5.8年,入选前所有患者均在接受口服降压药治疗,且服药时间均包含早餐前。监测患者早、午餐前5分钟及餐后2小时内每间隔15分钟的血压和心率。根据早餐后收缩压最大下降幅度将患者分为餐后低血压组(PPH,n=20)和非餐后低血压组(NPPH,n=34)。分析各组间生化指标及心脏超声心动图各指标有无差异。并将早餐前服药出现PPH现象患者的服药时间调整为早餐后2小时,再次监测餐后2小时服药EH患者早、午餐前后血压及心率,并与早餐前服药EH患者的血压及心率情况进行统计分析。结果:入选的EH住院患者早、午餐后PPH的检出率分别为37.04%、28.26%。随着年龄的增长和早餐前基础收缩压水平的升高,PPH的检出率和餐后收缩压最大下降幅度增加(P0.05)。调整PPH组患者服药时间后,早、午餐PPH的检出率分别显著降低至30.00%、25.00%(P0.05)。相关分析显示年龄与早餐后收缩压最大下降幅度呈正相关(r=0.515,P0.05);餐前SBP与早餐后SBP最大下降幅度呈正相关(r=0.609,P0.01)。Logistic回归分析显示年龄、早餐前基础收缩压是原发性高血压住院患者发生PPH的独立危险因素。结论:原发性高血压住院患者早餐后发生PPH的概率较高。早餐后2小时服用降压药可能会降低原发性高血压住院患者PPH的检出率。年龄和早餐前基础收缩压是原发性高血压住院患者PPH发生的独立危险因素。
[Abstract]:Objective: to observe the changes of blood pressure in patients with essential hypertension after breakfast and to explore the relationship between postprandial hypotension and the time of taking antihypertensive drugs. Methods: 54 hospitalized patients with essential hypertension were selected, including 30 males and 24 females, with an average age of 58.9 卤11.1 years and an average course of disease of 6.9 卤5.8 years. All patients were treated with oral antihypertensive drugs before admission. And the time of taking medicine includes before breakfast. Blood pressure and heart rate were monitored at intervals of 15 minutes before lunch and 2 hours after lunch. According to the maximum decrease of systolic blood pressure after breakfast, the patients were divided into postprandial hypotension group (PPH,n=20) and non-postprandial hypotension group (NPPH,n=34). The differences of biochemical indexes and cardiac echocardiography between the two groups were analyzed. The medication time of patients with PPH phenomenon before breakfast was adjusted to 2 hours after breakfast, and the blood pressure and heart rate of patients taking EH 2 hours after breakfast were monitored again. The blood pressure and heart rate of patients with EH before breakfast were statistically analyzed. Results: the detection rates of PPH in patients with EH were 37.04% and 28.26% respectively after lunch. With the increase of age and the increase of basal systolic blood pressure before breakfast, the detection rate of PPH and the maximum decrease of postmeal systolic blood pressure increased (P 0.05). After adjusting the medication time of patients in PPH group, the detection rate of PPH in brunch and lunch was significantly reduced to 30.00% and 25.00% respectively (P 0.05). Correlation analysis showed that age was positively correlated with the maximum decrease of systolic blood pressure after breakfast (r 鈮，

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