替罗非班联合氯吡格雷对老年急性冠脉综合征患者血小板功能、炎症因子及心功能的影响
发布时间：2019-06-19 09:47
【摘要】：目的探讨替罗非班联合氯吡格雷对老年急性冠脉综合征(ACS)患者血小板功能、炎症因子及心功能的影响。方法 116例老年ACS病例随机分为观察组(60例)和对照组(56例)。对照组在常规治疗的同时给予氯吡格雷,观察组在对照组的基础上给予替罗非班。治疗30 d后,观察两组血小板功能血栓烷(TX)B2、血小板2-颗粒膜蛋白(GMP)-140、血小板P-选择素(P-selectin)及炎症因子白细胞介素(IL)-6、肿瘤坏死因子(TNF)-α、C反应蛋白(CRP)及心功能左室射血分数(LVEF)、左室舒张末期内径(LVEDD)、左室收缩末期内径(LVESD)的变化。结果治疗后,两组TXB2、GMP-140、P-selectin、IL-6、TNF-α、CRP水平均明显下降,且观察组明显低于对照组(P0.05);治疗后,两组LVEF明显上升,而LVEDD、LVESD明显下降,观察组LVEF明显高于对照组,LVEDD、LVESD明显低于对照组(P0.05);两组不良反应比较无统计学意义(P0.05)。结论替罗非班联合氯吡格雷治疗老年ACS时抗血小板作用更强,且抑制炎症反应、改善心功能更显著。
[Abstract]:Objective to investigate the effects of tirofiban combined with clopidogrel on platelet function, inflammatory factors and cardiac function in elderly patients with acute coronary syndrome (ACS). Methods 116 elderly patients with ACS were randomly divided into observation group (n = 60) and control group (n = 56). The control group was given clopidogrel at the same time of routine treatment, and the observation group was given tirofiban on the basis of the control group. After 30 days of treatment, the changes of platelet functional thrombomane (TX) B2, platelet 2-granule membrane protein (GMP)-140, platelet P-selector (P-selectin), inflammatory factor (IL)-6, tumor necrosis factor (TNF)-伪, C-reactive protein (CRP) and cardiac function left ventricular ejection fraction (LVEF), left ventricular end-diastolic diameter (LVEDD), left ventricular end-systolic diameter (LVESD) were observed. Results after treatment, the levels of TXB2,GMP-140,P-selectin,IL-6,TNF- 伪 and CRP in the two groups were significantly decreased, and the levels of LVEF and CRP in the observation group were significantly lower than those in the control group (P 0.05). After treatment, LVEF in the two groups increased significantly, while LVEDD,LVESD decreased significantly. The LVEF in the observation group was significantly higher than that in the control group and LVEDD,LVESD was significantly lower than that in the control group (P 0.05). Conclusion tirofiban combined with clopidogrel has a stronger antiplatelet effect, suppresses inflammatory reaction and improves cardiac function in elderly patients with ACS.
【作者单位】： 武汉科技大学医院心血管神经内科;武汉科技大学医院药剂科;武汉科技大学附属天佑医院呼吸内科;
【分类号】：R541.4
[Abstract]:Objective to investigate the effects of tirofiban combined with clopidogrel on platelet function, inflammatory factors and cardiac function in elderly patients with acute coronary syndrome (ACS). Methods 116 elderly patients with ACS were randomly divided into observation group (n = 60) and control group (n = 56). The control group was given clopidogrel at the same time of routine treatment, and the observation group was given tirofiban on the basis of the control group. After 30 days of treatment, the changes of platelet functional thrombomane (TX) B2, platelet 2-granule membrane protein (GMP)-140, platelet P-selector (P-selectin), inflammatory factor (IL)-6, tumor necrosis factor (TNF)-伪, C-reactive protein (CRP) and cardiac function left ventricular ejection fraction (LVEF), left ventricular end-diastolic diameter (LVEDD), left ventricular end-systolic diameter (LVESD) were observed. Results after treatment, the levels of TXB2,GMP-140,P-selectin,IL-6,TNF- 伪 and CRP in the two groups were significantly decreased, and the levels of LVEF and CRP in the observation group were significantly lower than those in the control group (P 0.05). After treatment, LVEF in the two groups increased significantly, while LVEDD,LVESD decreased significantly. The LVEF in the observation group was significantly higher than that in the control group and LVEDD,LVESD was significantly lower than that in the control group (P 0.05). Conclusion tirofiban combined with clopidogrel has a stronger antiplatelet effect, suppresses inflammatory reaction and improves cardiac function in elderly patients with ACS.
【作者单位】： 武汉科技大学医院心血管神经内科;武汉科技大学医院药剂科;武汉科技大学附属天佑医院呼吸内科;
【分类号】：R541.4
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