肥厚性心肌病双心室流出道梗阻患者的临床分析

发布时间：2019-06-26 19:26

【摘要】：本文旨在总结分析肥厚性心肌病双心室流出道梗阻患者的临床特征。收集阜外医院2006年1月至2016年12月住院患者中经超声心动图或心脏磁共振证实存在双心室流出道梗阻的肥厚性心肌病患者的临床资料,与同期住院单(左)心室流出道梗阻(left ventricular outflow tract obstruction,LVOTO)肥厚性心肌病患者的资料相比,回顾性分析研究双心室流出道梗阻患者的临床特征、治疗情况及预后。结果表明:2006年1月至2016年12月,阜外医院住院患者中诊断为肥厚性梗阻型心肌病(hypertrophic obstructive cardiomyopathy,HOCM)患者共有151例,其中双心室流出道梗阻(BVOTO)患者15例(4.5%),与LVOTO组相比,BVOTO组平均诊断年龄更轻[(29.4±18.5)岁vs(39.9±13.1)岁,P0.01],NYHA心功能更差(BVOTO组Ⅲ级心功能以上者7例,46.7%,LVOTO组Ⅲ级心功能以上者16例,占12.1%,P0.01),合并恶性心律失常(房颤、室速)者比例更高(26.7%vs 13.3%,P0.05),有更高的心源性猝死风险。
[Abstract]:The purpose of this study was to summarize and analyze the clinical characteristics of patients with biventricular outflow tract obstruction in hypertrophic cardiomyopathy. The clinical data of hypertrophic cardiomyopathy with biventricular outflow tract obstruction confirmed by echocardiography or cardiac magnetic resonance imaging in Fuwai Hospital from January 2006 to December 2016 were collected. Compared with the data of patients with hypertrophic cardiomyopathy with single (left) ventricular outflow tract obstruction (left ventricular outflow tract obstruction,LVOTO) in Fuwai Hospital at the same time, the clinical characteristics, treatment and prognosis of patients with biventricular outflow tract obstruction were analyzed and studied. The results showed that from January 2006 to December 2016, there were 151 patients with hypertrophic obstructive cardiomyopathy (hypertrophic obstructive cardiomyopathy,HOCM), including 15 patients (4.5%) with biventricular outflow tract obstruction. Compared with LVOTO group, the average diagnostic age in BVOTO group was younger than that in BVOTO group [(29.4 卤18.5) years old vs (39.9 卤13.1) years, P 0.01]. The cardiac function of NYHA was worse (7 cases above grade III cardiac function, 46.7% in BVOTO group, 16 cases (12.1%) above grade III cardiac function in BVOTO group), and the proportion of patients with malignant tachyarrhythmia (26.7%vs 13.3%, P 0.05) was higher, and the risk of sudden cardiac death was higher.
【作者单位】：中国医学科学院北京协和医学院阜外医院国家心血管病中心心内科;
【基金】：高等学校博士学科点专项科研基金资助项目(20131106120009) 国家自然科学基金资助项目(81600305) 国家重点研发计划专项(2016YFC1300100)
【分类号】：R542.2

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