射频消融犬心室流出道间隔初步实验研究

发布时间：2019-07-01 14:33

【摘要】：目的初步探讨射频消融犬心室流出道间隔对左心室结构与功能的影响。方法以健康实验犬为模型,射频消融心室流出道间隔处肌肉。术前经胸超声检测左心室流出道宽度、收缩期室间隔厚度和射血分数等指标,消融成功后即刻检测超声指标,术后1、3个月分别复查存活犬超声指标,作组织病理学检查。结果 10只实验犬中9只消融成功,1只术中发生室颤死亡;1只消融成功但麻醉过深,出现呼吸抑制死亡。手术即刻成功率为80%,8只术后存活至预定随访时间点。与术前相比,存活犬术后即刻、术后1个月、术后3个月左心室流出道宽度、收缩期室间隔厚度差异均有统计学意义(P0.05),射血分数差异均无统计学意义(P0.05);组织病理学检查可见明显改变;心电图、血压未见明显变化。结论初步验证射频消融实验犬心室流出道间隔心肌具有一定的安全性和有效性,为进一步动物实验和临床试验提供了有用参数和实验依据。
[Abstract]:Objective to investigate the effect of radiofrequency ablation of ventricular outflow tract septum on left ventricular structure and function in dogs. Methods the muscle of ventricular outflow tract septum was ablation by radiofrequency ablation in healthy dogs. The width of left ventricular outflow tract, the thickness of interventricular septum and ejection fraction were measured by transthoracic ultrasound before operation, and the ultrasonic indexes were measured immediately after successful ablation. The ultrasonic indexes of surviving dogs were reviewed 1 month and 3 months after operation, and the pathological examination was performed. Results among 10 experimental dogs, 9 dogs underwent successful ablation, 1 died of ventricular fibrillation during operation, and 1 dog died of respiratory inhibition due to successful ablation but deep anesthesia. The immediate success rate was 80%. Eight patients survived until the scheduled follow-up time. Compared with before operation, there were significant differences in left ventricular outflow tract width and systolic interventricular septum thickness between survival dogs immediately after operation, 1 month after operation and 3 months after operation (P 0.05), but there was no significant difference in ejection fraction (P 0.05). There were significant changes in histopathological examination and no significant changes in electrocardiogram and blood pressure. Conclusion radiofrequency ablation is safe and effective in canine ventricular outflow septum myocardium, which provides useful parameters and experimental basis for further animal and clinical trials.
【作者单位】：第二军医大学附属长海医院心血管内科;
【分类号】：R542.2

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