血过氧化物酶体增殖因子活化受体γ、胱抑素C与老年动脉粥样硬化的相关性

发布时间：2019-07-21 20:14

【摘要】：目的测定健康成年人及老年动脉粥样硬化(AS)患者的血过氧化物酶体增殖因子活化受体(PPAR)γ基因表达及胱抑素C含量,探讨该两项指标与AS程度的相关性。方法选取健康体检成年人40例为健康对照组。选取老年2型糖尿病患者共80例,彩超检查均提示有颈动脉内膜增厚伴斑块形成。测定肱-踝动脉脉搏波速度(ba PWV)及踝肱指数(ABI),左右两侧均满足1 200 cm/sba PWV2 000 cm/s且0.8ABI1.0者为轻度AS组,均满足ba PWV≥2 000 cm/s且ABI≤0.8者为重度AS组,每组各40例。检测三组患者血浆PPARγ基因表达及血清胱抑素C含量。结果健康对照组、轻度AS组、重度AS组的PPARγ基因表达灰度分别为(37 361.11±12 742.51)、(50 619.15±17 782.41)、(80 349.33±21 003.19),胱抑素C浓度分别为(0.83±0.15)mg/L、(0.88±0.26)mg/L、(0.94±0.33)mg/L;三组PPARγ差异显著(P0.01),胱抑素C含量无统计学差异(P0.05);PPARγ基因灰度与AS严重度呈明显正相关(r=0.61,P0.01)。结论 PPARγ与AS有密切关系,其血浆水平可能是反映AS严重程度的指标。
[Abstract]:Objective to detect the expression of serum peroxisome proliferator activating receptor (PPAR) 纬 gene and the content of cystine C in healthy adults and elderly patients with atherosclerotic (AS), and to explore the correlation between these two indexes and the degree of AS. Methods 40 healthy adults were selected as healthy control group. A total of 80 elderly patients with type 2 diabetes mellitus were selected. Color Doppler ultrasound showed carotid intima thickening with plaque formation. The pulse wave velocity of brachial-ankle artery (ba PWV) and ankle-brachial index (ABI),) were measured at 1200 cm/sba PWV2 000 cm/s and 0.8ABI1.0 in mild AS group, ba PWV 鈮，

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