丹参多酚酸盐联合苯扎贝特治疗缺血性心肌病的临床观察

发布时间：2019-08-04 12:08

【摘要】：目的:探讨丹参多酚酸盐联合苯扎贝特对缺血性心肌病患者临床疗效、炎症因子和心室功能的影响及安全性。方法:选取2015年3月-2016年3月我院收治的缺血性心肌病患者138例,按照随机数字表法分为观察组和对照组,各69例。对照组患者给予苯扎贝特分散片0.2 g,po,tid;观察组患者在对照组基础上给予注射用丹参多酚酸盐200 mg加至0.9%氯化钠注射液250 m L中,ivgtt,qd。两组患者均以14 d为1个疗程,均治疗2个疗程。比较两组患者的临床疗效、血清炎症因子[C反应蛋白(CRP)、肿瘤坏死因子α(TNF-α)、白细胞介素6(IL-6)、基质金属蛋白酶9(MMP-9)和单核细胞趋化蛋白1(MCP-1)]和心功能指标[左室收缩末期内径(LVESD)、左室舒张末期内径(LVEDD)和左室射血分数(LVEF)],并记录不良反应发生情况。结果:观察组患者的总有效率(97.10%)明显高于对照组(86.96%),差异有统计学意义(P0.05)。治疗前,两组患者血清CRP、TNF-α、IL-6、MMP-9、MCP-1、LVESD、LVEDD和LVEF水平比较,差异均无统计学意义(P0.05);治疗后,两组患者CRP、TNF-α、IL-6、MMP-9、MCP-1、LVESD和LVEDD水平均明显降低,LVEF明显升高,且观察组较对照组改善更明显,差异均有统计学意义(P0.05)。两组患者治疗过程中均未见明显的不良反应发生。结论:丹参多酚酸盐联合苯扎贝特治疗缺血性心肌病效果显著,可降低患者血清炎症因子水平,改善心功能,且安全性较高。
[Abstract]:Objective: to investigate the clinical efficacy, inflammatory factors and ventricular function of Salvia miltiorrhiza polyphenols combined with benzabet in patients with ischemic cardiomyopathy. Methods: 138 patients with ischemic cardiomyopathy treated in our hospital from March 2015 to March 2016 were randomly divided into observation group (n = 69) and control group (n = 69). The patients in the control group were given buzabet dispersible tablets 0.2 g, postetid. on the basis of the control group, the patients in the observation group were given salvia miltiorrhiza polyphenols 200 mg plus 0.9% sodium chloride injection 250 mL, ivgtt,qd. The patients in both groups were treated with 14 days as a course of treatment and 2 courses of treatment. The clinical efficacy of serum inflammatory factors [C-reactive protein (CRP), tumor necrosis factor 伪 (TNF- 伪), IL-6 (IL-6), matrix metalloprotease 9 (MMP-9) and monocyte chemoattractant protein 1 (MCP-1)] and cardiac function indexes [left ventricular end-systolic diameter (LVESD), left ventricular end-diastolic diameter (LVEDD) and left ventricular ejection fraction (LVEF)] were compared between the two groups. The occurrence of adverse reactions was recorded. Results: the total effective rate of the observation group (9710%) was significantly higher than that of the control group (86.96%), the difference was statistically significant (P 0.05). Before treatment, there was no significant difference in serum CRP,TNF- 伪, IL-6,MMP-9,MCP-1,LVESD,LVEDD and LVEF levels between the two groups (P 0.05). After treatment, the levels of CRP,TNF- 伪, IL-6,MMP-9,MCP-1,LVESD and LVEDD in the two groups were significantly decreased and LVEF was significantly higher than that in the control group, and the difference was statistically significant (P 0.05). No obvious adverse reactions were found in both groups during treatment. Conclusion: Salvia miltiorrhiza polyphenols combined with benzabet is effective in the treatment of ischemic cardiomyopathy, which can reduce the level of serum inflammatory factors and improve cardiac function, and the safety is high.
【作者单位】：唐山市工人医院急诊科;唐山市工人医院感染科;唐山市工人医院心血管内科;
【基金】：唐山市科学技术研究与发展计划项目(No.10130246a)
【分类号】：R542.2

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