视网膜血管直径与糖尿病及其视网膜病变相关关系研究：邯郸眼病研究

发布时间：2018-01-16 22:26

本文关键词：视网膜血管直径与糖尿病及其视网膜病变相关关系研究：邯郸眼病研究　出处：《天津医科大学》2014年博士论文　论文类型：学位论文

【摘要】：目的:高血压、糖尿病等全身系统性疾病以及不同程度的视网膜病变对视网膜血管直径有不同程度的影响。不同的人群研究对视网膜血管直径的影响趋势及程度报道却不同。本研究旨在了解中国北方农村人群中视网膜血管直径与血糖水平、糖尿病以及视网膜病变之间的相关关系方法:邯郸眼病研究是以人群为基础的研究,在河北省邯郸市永年县随机抽取13个村的30岁以上人群共6830人进行全面的眼科和全身检查。采用眼底数码照相并对眼底照片进行视网膜病变程度的读片,采用计算机辅助的软件对视网膜血管直径进行测量。结果:共2897人为正常空腹血糖,1923人为空腹血糖受损,109人有糖尿病视网膜病变体征,另218例糖尿病患者尚未有视网膜病变。经多元回归分析,血糖正常组、空腹血糖受损组和糖尿病组视网膜动脉直径分别为157.6 μm、153.9μm和153.7 μm(P0.001);视网膜静脉直径分别为239.4 μm、236.3μm和242.1μm(P0.001)。视网膜动脉直径每增加一个标准差发生糖尿病的危险减少(OR=0.67,95%CI:0.52～0.86),糖尿病患者发生视网膜病变的危险减少(OR=0.46,95%CI:0.28～0.76)。视网膜静脉直径每增加一个标准差,发生糖尿病的风险增加(OR=1.38,95%CI:1.08～1.76),糖尿病患者发生视网膜病变的风险增加(OR=2.02,95%CI:1.24～17.15)。结论:糖尿病患者视网膜动脉直径较小、静脉直径较大,同时糖尿病患者有视网膜病变者视网膜动脉直径较小、静脉直径较大。视网膜血管直径与糖尿病、糖尿病视网膜病变之间的相关关系可能反应在糖尿病视网膜病变早期微血管损害的病理生理过程。
[Abstract]:Objective: hypertension. Systemic diseases such as diabetes mellitus and different degrees of retinopathy have different effects on the diameter of retinal vessels. The trend and extent of the effects of different population studies on retinal vascular diameter are different. The aim of the study was to understand the retinal vascular diameter and blood glucose level in rural population of northern China. The correlation between diabetes mellitus and retinopathy methods: the Handan eye disease study is a population-based study. A total of 6 830 people aged 30 and over were randomly selected from 13 villages of Yongnian County Handan Hebei Province for a comprehensive ophthalmology and general examination. Digital photography of the fundus was used to read the degree of retinopathy. The film. The diameter of retinal vessels was measured by computer aided software. Results: a total of 2 897 people were normal fasting blood glucose and 1 923 were impaired fasting blood glucose. 109 patients had diabetic retinopathy signs. The diameter of retinal artery was 157.6 渭 m in normal glucose group, impaired fasting blood glucose group and diabetic group by multiple regression analysis. 153.9 渭 m and 153.7 渭 m (P 0.001); The diameter of retinal vein was 239.4 渭 m. 236.3 渭 m and 242.1 渭 m P0.001g. The risk of developing diabetes with each additional standard deviation of retinal artery diameter decreased by 0.67. The risk of retinopathy in diabetic patients was reduced to 0.46 by 95 CI: 0.52 / 0.86. 95 CI: 0.28 / 0.76. For every additional standard deviation in the diameter of the retinal vein, the risk of developing diabetes is increased by 1.38% CI: 1.08% 1.76). The risk of retinopathy was increased in diabetic patients. Conclusion: retinal artery diameter and vein diameter are smaller and larger in diabetic patients. At the same time, the diameter of retinal artery and vein were smaller in patients with diabetic retinopathy. The correlation between diabetic retinopathy may reflect the pathophysiological process of microvascular damage in the early stage of diabetic retinopathy.
【学位授予单位】：天津医科大学
【学位级别】：博士
【学位授予年份】：2014
【分类号】：R774.1;R587.2

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