碱性成纤维细胞生长因子止血绫浸片与膨胀海绵联用治疗血液病鼻出血

发布时间：2018-03-03 07:55

本文选题：鼻出血　切入点：鼻腔填塞　出处：《临床耳鼻咽喉头颈外科杂志》2014年02期 　论文类型：期刊论文

【摘要】：目的:观察重组牛碱性成纤维细胞生长因子(rb-bFGF)止血绫浸片与膨胀海绵联合在治疗血液病鼻出血的应用效果。方法:前瞻性研究选取2009-01-2011-02期间血液病鼻出血患者96例,随机分为两组:治疗组50例,对照组46例,均经鼻内镜检查明确出血部位。治疗组应用rb-bFGF止血绫浸片联合膨胀海绵行前鼻孔填塞止血治疗,对照组应用凡士林纱进行鼻腔填塞。每例患者均对填塞后鼻腔疼痛评分和止血效果进行分析比较。结果:治疗组与对照组比较,止血效果差异无统计学意义,但填塞后再出血率、填塞不同时间鼻腔疼痛程度,治疗组明显低于对照组,差异有统计学意义(P0.05)。结论:rb-bFGF吸收性止血绫浸片联合膨胀海绵止血效果确切、创伤小、拔出填塞时鼻腔再出血发生率低且鼻腔填塞痛苦少,适合血液病鼻出血的局部填塞治疗。
[Abstract]:Objective: to observe the effect of recombinant bovine basic fibroblast growth factor rb-bFGF( rb-bFGF) hemostatic damask extract tablets combined with bloating sponge in the treatment of epistaxis of hematologic diseases. Methods: 96 patients with hematological epistaxis from 2009-01-2011-02 were selected in a prospective study. The patients were randomly divided into two groups: treatment group (n = 50) and control group (n = 46). The treatment group was treated by nasal endoscopy to determine the bleeding location. In the control group, the nasal cavity was filled with vaseline gauze. The scores of nasal cavity pain and hemostatic effect were analyzed and compared in each patient. Results: there was no significant difference in hemostatic effect between the treatment group and the control group. However, the rate of rebleeding after tamponade and the degree of nasal pain in the treatment group were significantly lower than those in the control group, and the difference was statistically significant (P 0.05). The incidence of recurrent bleeding in nasal cavity is low and the pain of nasal packing is less, so it is suitable for local packing treatment of hematologic epistaxis.
【作者单位】：唐山市工人医院耳鼻咽喉科;
【分类号】：R765.23

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