硅油填充继发青光眼患者前房液中生长因子含量变化的相关分析

发布时间：2018-04-01 23:22

本文选题：硅油填充眼　切入点：继发性青光眼　出处：《大连医科大学》2011年硕士论文

【摘要】：目的:通过测定硅油填充继发性青光眼患者前房水中血管内皮生长因子及碱性成纤维细胞生长因子的水平,探讨硅油填充在继发性青光眼中的潜在作用,以及前房水中生长因子含量的改变与眼压之间的关系。方法:用双抗体夹心酶联免疫吸附法(ELISA)定量检测各组房水中VEGF和bFGF含量。实验分组如下:①老年性白内障患者18例20眼作为正常对照组②硅油填充继发性青光眼患者16例16眼作为患者组(SOF组)③复杂性孔源性视网膜脱离眼(CRD组)16例16眼。各组之间年龄、性别差异无统计学意义(P0.05)。结果:SOF组患者眼前房水中VEGF含量明显高于正常对照组和CRD组,bFGF含量明显低于正常对照组和CRD组,其差异均具有统计学意义(P0.05);SOF组患者前房水中VEGF的含量与眼压及硅油填充时间呈正相关(r分别为0.905、0.915,P0.05),bFGF含量与眼压及硅油填充时间无明显相关性。CRD组和正常对照组比较,前房水中VEGF和bFGF差异均无统计学意义(P0.05)。结论:硅油填充继发青光眼患者眼前房水中VEGF含量明显增高,bFGF含量明显降低,提示二者在硅油填充继发青光眼的病程发展中具有一定作用。
[Abstract]:Objective: to investigate the potential role of silicone oil in secondary glaucoma by measuring the levels of vascular endothelial growth factor (VEGF) and basic fibroblast growth factor (bFGF) in anterior aqueous humor of patients with secondary glaucoma.And the relationship between the change of growth factor content in anterior chamber water and intraocular pressure.Methods: double antibody sandwich enzyme linked immunosorbent assay (Elisa) was used to determine the content of VEGF and bFGF in aqueous humor.There were 18 cases (20 eyes) of senile cataract as normal control group. 16 cases (16 eyes) of secondary glaucoma were treated as SOF group (n = 16), 16 cases (16 eyes) with complex rhegmatogenous retinal detachment (CRD) and 16 cases (16 eyes) with complicated rhegmatogenous retinal detachment (CRD).There was no significant difference in age and sex between each group (P 0.05).Results the content of VEGF in aqueous humor of patients in the control group was significantly higher than that in the normal control group and the CRD group, which was significantly lower than that in the normal control group and CRD group.There was no significant correlation between the content of VEGF in anterior chamber water and intraocular pressure (IOP) and the filling time of silicone oil (r = 0.905) and the time of intraocular pressure (IOP) and silicone oil filling (r = 0.905), respectively. There was no significant correlation between VEGF content and intraocular pressure (IOP) and silicone oil filling time (P > 0.05), and there was no significant correlation between VEGF content and intraocular pressure (IOP) and silicone oil filling time (P > 0.05).There was no significant difference between VEGF and bFGF in anterior chamber water (P 0.05).Conclusion: the content of VEGF in aqueous humor of patients with secondary glaucoma filled with silicone oil is obviously increased and the content of bFGF is obviously decreased, which suggests that both of them may play a role in the course and development of secondary glaucoma with silicone oil.
【学位授予单位】：大连医科大学
【学位级别】：硕士
【学位授予年份】：2011
【分类号】：R779.6

【参考文献】