无创呼吸机联合丹红治疗中老年COPD伴OSAHS重叠综合征患者认知障碍的疗效

发布时间：2018-04-28 23:39

本文选题：重叠综合征 + 认知障碍　；参考：《中国老年学杂志》2014年22期

【摘要】：目的探讨无创呼吸机联合丹红治疗中老年慢性阻塞性肺病(COPD)伴阻塞性睡眠呼吸暂停低通气综合征(OSAHS)重叠综合征患者认知障碍的疗效。方法选择诊为重叠综合征的中老年患者为A组,同期查体者为对照组(B组)。两组均接受蒙特利尔(Mo CA)量表测试,分为有及无认知功能障碍两组,测定其血清同型半胱氨酸(Hcy)、低氧诱导因子(HIF)-1α。对A组合并认知障碍者给予无创呼吸机联合丹红治疗,比较治疗前后指标变化。结果合并认知功能障碍者血清Hcy及HIF-1α浓度高于未合并组(P0.05)。A组认知障碍者Mo CA评分低于B组合并者(P0.05);A组认知障碍者治疗后血清Hcy及HIF-1α水平下降,Mo CA量表评分升高(P0.05)。结论接受无创呼吸机联合丹红治疗可以改善中老年重叠综合征患者认知障碍。
[Abstract]:Objective to investigate the efficacy of non invasive Ventilator Combined with Danhong in the treatment of cognitive disorders in patients with chronic obstructive pulmonary disease (COPD) with obstructive sleep apnea hypopnea syndrome (OSAHS) syndrome in the middle and old age. Methods the middle aged and elderly patients with overlapping syndrome were selected as group A, and those in the same period were the control group (group B). The two groups were all received Montreal. (Mo CA) scale test, divided into two groups with and without cognitive impairment, determine serum homocysteine (Hcy) and hypoxia inducible factor (HIF) -1 alpha. Non invasive Ventilator Combined with red red therapy for A combination and cognitive impairment were given, and the changes of indexes before and after treatment were compared. The concentrations of serum Hcy and HIF-1 a in patients with cognitive dysfunction were higher than that of non combination. The Mo CA score of group.A group (P0.05) was lower than that of B group (P0.05); the level of serum Hcy and HIF-1 alpha in the A group was decreased, and the Mo CA scale score increased (P0.05). Conclusion acceptance of non invasive Ventilator Combined with Danhong can improve cognitive impairment in patients with middle and old age overlapping syndrome.

【作者单位】：天津中医药大学研究生院;河北联合大学附属医院呼吸科;河北联合大学附属医院内分泌科;天津市第一中心医院重症医学科;
【基金】：河北省科技厅科学技术研究与发展计划项目(09276103D11)
【分类号】：R563.9;R766

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