大龄弱视六小时与全天遮盖及服药后视力与视功能的研究

发布时间：2018-05-07 23:32

本文选题：远视性屈光参差性弱视 + 6小时遮盖　；参考：《昆明医学院》2011年硕士论文

【摘要】：研究目的 1.探讨9-12岁远视性屈光参差性弱视患者6小时遮盖与全天遮盖治疗的中心视力和近立体视(Titmus)的疗效上是否有差异。 2.探讨9-12岁远视性屈光参差性弱视患者6小时遮盖与全天遮盖中口服胞磷胆碱钠片组与未服药组的视功能是否有差异。研究方法 1.将150例9-12岁远视性屈光参差性弱视患者根据弱视的轻、中、重程度随机分为6小时遮盖组以及全天遮盖组,在遮盖治疗基础上都行精细训练治疗,随访分别在第1,4,10个月,同时记录患者最佳矫正视力和戴镜Titmuso 2.10个月后将两个遮盖组轻度、中度弱视患者随机分为服药组及未服药组。服药组在遮盖治疗的基础上给予胞磷胆碱钠片口服1个月,各组随访4个月,记录患者图形视觉诱发电位(P-VEP), Titmus,以及对比敏感度(CS)的变化情况。另外,严密观察服药组各种可能的副作用,直至本临床试验结束时,未发现一例副作用患者。 3.采用SPSS11.5对视力及视功能等结果进行统计学分析处理。研究结果 1.轻度、中度患者,6小时遮盖与全天遮盖视力提高无统计学差异(p0.05)；轻度、中度患者,6小时遮盖与全天遮盖立体视增长有统计学差异(p0.05)； 2.中度弱视患者,服药组与未服药组的P-VEP有统计学差异(p0.05),在六小时遮盖治疗中,服药组与未服药组近立体视有统计学差异(p0.05);服药组中,6小时遮盖与全天遮盖近立体视对比有统计学差异(p0.05)；对比敏感度检查为药物治疗弱视患者视功能的改善提供参考依据。研究结论 1.对于9-12岁远视性屈光参差性弱视轻度、中度患者6小时遮盖与全天遮盖视力都有提高,且无统计学差异：Titmus检查的立体视锐度6小时遮盖立体视增长优于全天遮盖。 2.胞磷胆碱钠片在遮盖治疗的基础上对弱视患者的视功能提高上有相对的辅助作用。
[Abstract]:Purpose of research 1. To explore whether there is a difference in the treatment of central vision and near stereopsis between patients aged 9-12 years old with hyperopic anisometropia amblyopia. 2. To investigate the difference of visual function between patients with hyperopic anisometropia amblyopia (9-12 years old) who were treated with oral citicoline sodium tablets for 6 hours or all day. Research method 1. 150 cases of hyperopic anisometropia amblyopia aged 9-12 years were randomly divided into 6 hour shaded group and full day covering group according to the degree of amblyopia. At the same time, the best corrected visual acuity and Titmuso were recorded. After 2. 10 months, the patients with mild and moderate amblyopia were randomly divided into two groups. The patients in the drug group were treated with citicoline sodium tablets for 1 month on the basis of shaded treatment. The patients were followed up for 4 months to record the changes of graphic visual evoked potential (P-VEP), Titmus and contrast sensitivity (CSS). In addition, all possible side effects in the drug group were closely observed until the end of the clinical trial, no side effects were found. 3. Visual acuity and visual function were statistically analyzed by SPSS11.5. Research results 1. There was no significant difference in visual acuity between light and moderate patients with 6 hours covering and all day covering, while there was a significant difference in the increase of stereopsis between light and moderate patients with 6 hours covering and all day covering. 2. In patients with moderate amblyopia, there was a significant difference in P-VEP between the drug group and the control group (P 0.05). There were significant differences in the near stereopsis between the drug group and the control group (P 0.05), and in the treatment group there was a significant difference between the 6 hour cloak and the whole day covering near stereopsis. The contrast sensitivity test provided a reference for the improvement of the visual function of the patients with amblyopia treated with drugs. Research conclusion 1. For hyperopic anisometropia amblyopia of 9-12 years old, the visual acuity of 6-hour covering and all-day covering in moderate patients were improved, and the stereopsis acuity of 6-hour covering was better than that of all-day covering. 2. Citicoline sodium tablets can improve the visual function of amblyopia patients on the basis of covering therapy.
【学位授予单位】：昆明医学院
【学位级别】：硕士
【学位授予年份】：2011
【分类号】：R777.44

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