自体富血小板血浆对角膜碱烧伤组织修复的影响

发布时间：2018-06-02 16:54

本文选题：自体富血小板血浆 + 组织修复　；参考：《中国现代医学杂志》2014年32期

【摘要】：目的观察自体富血小板血浆对角膜碱烧伤的治疗作用。方法采用随机数字表法将88例92眼患者随机分为对照组和试验组,分别于给药前及给药后7、14、21、28 d于裂隙灯下观察各组眼的角膜溃疡和炎症反应,参照Ando等的评分标准对角膜炎症进行评分,行角膜上皮荧光素钠染色,记录患眼角膜溃疡面积的大小,并参照Trousdale评分标准对角膜溃疡进行评分。结果治疗后14和21 d,对照组和试验组的总有效率分别为14.89%和17.78%,以及68.08%和84.44%,两组间差异无统计学意义(P0.05);治疗后28 d,对照组和试验组总有效率分别为80.85%和95.56%,两组间差异有统计学意义(P0.05)。所有患者都有不同程度的角膜斑翳,但试验组角膜的透明性要好于对照组;对照组13眼有角膜新生血管,试验组只有3眼有角膜新生血管,两组间差异有统计学意义(P0.05)。结论自体富血小板血浆对角膜碱烧伤组织具有明显的修复作用,且无过敏和疾病的传播。
[Abstract]:Objective to observe the therapeutic effect of autologous platelet-rich plasma on alkali burn of cornea. Methods Eighty-eight patients (92 eyes) were randomly divided into two groups: control group and experimental group. Corneal ulcer and inflammatory reaction were observed under slit lamp before and after administration of the drug. The corneal inflammation was scored according to Ando et al. Corneal epithelial fluorescein sodium staining was used to record the size of corneal ulcer area and the corneal ulcer was scored according to Trousdale scoring standard. Results the total effective rates of the control group and the experimental group were 14.89% and 17.78% and 68.08% and 84.44% respectively on the 14th and 21st days after treatment, and there was no significant difference between the two groups (P 0.05), and the total effective rates of the control group and the experimental group were 80.85% and 95.56 at 28 days after treatment, respectively, with the difference between the two groups. The difference was statistically significant (P 0.05). All the patients had different degrees of corneal pannus, but the corneal transparency in the experimental group was better than that in the control group, and the corneal neovascularization was found in 13 eyes in the control group and in 3 eyes in the experimental group, the difference between the two groups was statistically significant (P 0.05). Conclusion Autologous platelet-rich plasma can repair corneal alkali burn tissue without allergy and disease spread.
【作者单位】：南昌大学第二附属医院儿童眼科;
【分类号】：R779.1

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