0.005%拉坦前列腺素与0.5%马来酸噻吗洛尔的固定合剂治疗原发性开角型青光眼及高眼压症的降眼压效果有效性的系统评价
发布时间：2018-07-20 19:26
【摘要】：目的：比较与评价FCLT与β-受体阻滞剂类对于POAG和OHT患者的降眼压效果 方法：检索了CENTRAL, MEDLINE, EMBASE,以及SCI。采用对照组为β-受体阻滞剂类降眼压药物,试验对象为POAG或OHT患者随机对照试验或交叉试验,使用MD作为结局指标。 结果：共8个临床试验符合标准,纳入受试对象1808人。FCLT每天使用一次与噻吗洛尔相比可以更有效的降低日平均眼压(MD-2.95[-3.34,-2.56], P0.00001)和24小时平均眼压(MD-2.84[-3.57,-2.12], P0.00001)。而且可以减小眼压波动(MD-0.85[-1.18,-0.53],P0.00001)。 结论：FCLT用于POAG和OHT的患者,其降低日平均眼压和24小时平均眼压的效果更好,减小了眼压的波动。对于24小时眼压的结果需要更多的高质量随机对照试验的进一步证实。 目的：比较与评价FCLT与前列腺素类药物对于POAG和OHT患者的降眼压效果 方法：检索了CENTRAL, MEDLINE, EMBASE,以及SCI。采用对照组为前列腺素类类降眼压药物,试验对象为POAG或OHT患者随机对照试验或交叉试验,使用MD作为结局指标。 结果：共12个临床试验符合标准,纳入受试对象2534人。FCLT与拉坦前列腺素相比可以更有效的降低日平均眼压(MD-1.13[-1.47,-0.79], P0.00001),和24小时平均眼压(MD-2.50[-3.58,-1.42], P0.00001)。而且可以减小眼压波动(MD-0.65[-1.02,-0.27],P=0.0007)。 FCLT与曲伏前列腺素相比在降低日平均眼压方面没有明显差别(MD0.05[-0.19,0.29], P=0.68)。 FCLT与贝美前列腺素相比降24小时平均眼压效果没有明显差异(MD0.20[-0.44,0.85], P=0.53)。 结论：FCLT用于POAG和OHT的患者,与拉坦前列腺素相比,其降低日平均眼压和24小时平均眼压的效果更好,减小了眼压的波动。与曲伏前列腺素和贝美前列腺素相比,降眼压的效果没有明显差别。对于24小时眼压的结果需要更多的高质量随机对照试验的进一步证实。 目的：比较与评价FCLT与其成分药物联合应用对于POAG和OHT患者的降眼压效果 方法：检索了CENTRAL, MEDLINE, EMBASE,以及SCI。采用对照组为0.005%拉坦前列腺素与0.5%马来酸噻吗洛尔联合应用,试验对象为POAG或OHT患者随机对照试验或交叉试验,使用MD作为结局指标。 结果：共3个临床试验符合标准,纳入受试对象961人。当FCLT早上使用时日平均眼压比其成分药物联合应用高(MD1.10[0.81,1.39], P0.00001), FCLT晚上使用时,平均眼压没有明显差别(MD0.42[-0.06,0.89], P=0.09) 结论：对于POAG和OHT的患者,当FCLT早上使用时,与其成分药物联合应用相比,其降低日平均眼压的效果较差,当FCLT晚上使用时,它们降眼压效果没有明显差别。 目的：比较与评价FCLT与其它前列腺素类与噻吗洛尔的固定合剂对于POAG和OHT患者的降眼压效果 方法：检索了CENTRAL, MEDLINE, EMBASE,以及SCI。采用对照组为其它前列腺素类与噻吗洛尔的固定合剂,试验对象为POAG或OHT患者随机对照试验或交叉试验,使用MD作为结局指标。 结果：共5个临床试验符合标准,纳入受试对象720人。FCLT与0.004%曲伏前列腺素/0.5%噻吗洛尔的固定合剂(FCTT, the fixed combination of0.004%tranvoprost and0.5%timolol)比较,当两种药物晚上使用时,FCLT组的日平均眼压较低(MD-1.84[-3.34,-0.34], P=0.02)。FCLT与0.03%贝美前列腺素和0.5%噻吗洛尔的固定合剂(FCBiT, the fixed combination of0.03%bimatroprost and0.5%timolol)相比,日平均眼压较高(MD0.78[0.50,1.06], P0.00001),白天的眼压波动较高(MD1.10[0.45,1.75]],P=0.0009) 结论：对于POAG和OHT的患者,FCLT对于日平均眼压及眼压波动的控制不如FCBiT,对于日平均眼压的控制优于FCTT。需要高质量的随机对照研究来证实与FCTT,FCBiT相比日平均眼压的情况,以及24小时平均眼压的情况。 目的：比较与评价FCLT与其它固定合剂对于POAG和OHT患者的降眼压效果 方法：检索了CENTRAL, MEDLINE, EMBASE,以及SCI。采用对照组为其它类型的固定合剂,试验对象为POAG或OHT患者随机对照试验或交叉试验,使用MD作为结局指标。 结果：共9个临床试验符合标准,纳入受试对象732人。FCLT比2%多佐胺/0.5%噻吗洛尔固定合剂(FCDT, the fixed combination of2%dorzolamide and0.5%timolol)降低平均眼压效果更佳(MD-0.59[-0.91,-0.26] P=0.0004)。对于眼压波动的控制两者无明显差别(MD-0.25[-0.98,0.47] P=0.49)o FCLT与0.2%溴莫尼定/0.5%噻吗洛尔固定合剂(FCBT, the fixed combination of0.2%brimonidine and0.5%timolol)降低日平均眼压的效果无明显差别(MD-0.50[-2.07,1.07] P=0.53)。 结论：对于POAG和OHT的患者,FCLT降低日平均眼压的效果优于FCDT。 FCLT控制眼压波动与FCDT无明显差别,FCLT与FCBT降低日平均眼压效果无明显差别。仍需要高质量的随机对照眼压进一步证实它们对日平均眼压以及24小时均眼压的影响。
[Abstract]:Objective : To compare and evaluate the IOP - lowering effect in patients with POAG and OHT in patients with POAG and OHT .
Methods : The subjects were randomly controlled trial or cross test of POAG or OHT , and MD was used as the outcome measure .
Results : The average intraocular pressure ( MD - 2.95 % - 3.34 , - 2.56 mmol , P0.001 ) and 24 - hour mean intraocular pressure ( MD - 2.84 - 3.57 , - 2.12 , P - 0.001 ) could be more effective than that of tiotropium . but also can reduce the fluctuation of intraocular pressure ( MD - 0.85 - 1.18 , - 0.53 billion , P0.001 ) .
Conclusion : The results showed that patients with POAG and OHT decreased the daily average intraocular pressure and the average intraocular pressure in 24 hours , and decreased the fluctuation of intraocular pressure .
Objective : To compare and evaluate the IOP lowering effect in patients with POAG and OHT in patients with POAG and OHT .
Methods : CENTRAL , EMBASE , and SCI were retrieved . The control group was used as prostaglandin - like pressure - lowering drugs . The subjects were either POAG or OHT patients randomized controlled trial or crossover trial , and MD was used as the outcome measure .
Results : There were 12 clinical trials in compliance with the criteria and included 2534 subjects in the test subjects . The daily average intraocular pressure ( MD - 1.13 , - 1 . 47 , - 0.79 diopter , P0.001 ) and 24 - hour mean intraocular pressure ( MD - 2.50 - 3.58 , - 1.42 ug , P0.001 ) were more effective than that of latanoprost . Also , IOP fluctuations ( MD - 0.65 - 1.02 , - 0.27 sqm , P = 0.0007 ) can be reduced . There was no significant difference in the mean ocular pressure ( MD0.05 ~ - 0.19 , 0.29 mmol , P = 0.68 ) than that of TPV . There was no significant difference in mean intraocular pressure ( MD0.20 - 0.44 , 0.85 mmol , P = 0.53 ) compared with the 24 - hour mean IOP reduction compared with BU.S . prost .
Conclusion : The results showed that patients with POAG and OHT had better effects on average intraocular pressure and IOP after 24 hours than that of latanoprost . The results showed that the effect of IOP was not significantly different .
Objective : To compare and evaluate the effect of combined therapy with the combination of the components in the patients with POAG and OHT .
Methods : CENTRAL , EMBASE , and SCI were retrieved . The control group was used in combination with 0.005 % latanoprost and 0.5 % thiadiazole lol . The subjects were either POAG or OHT patients randomized controlled trial or crossover trial , and MD was used as the outcome measure .
Results : Three clinical trials met the criteria and were included in 961 subjects . The average intraocular pressure was higher than that of its components ( MD1 . 10 卤 0.81 , 1 . 39 渭g , P 0 . 00001 ) . The mean intraocular pressure was not significantly different ( MD0.42 卤 0.06 , 0.89 掳 , P = 0.09 ) .
Conclusion : For patients with POAG and OHT , the effect of decreasing daily average intraocular pressure is less than that of the combined application of the components in the patients with POAG and OHT .
Objective : To compare and evaluate the IOP - lowering effect of the fixed mixture of FCLs and other prostaglandin and thiadiazole in patients with POAG and OHT .
Methods : CENTRAL , EMBASE , and SCI were retrieved . The control group was used as the fixed mixture of other prostaglandin and thiadiazole , and the subjects were either POAG or OHT patients randomized controlled trial or crossover trial , and MD was used as the outcome measure .
Results : A total of 5 clinical trials met the criteria and were included in the 720 human subjects of the test subjects . Compared with the fixed combination of 0.004 % travoprost and0.5 % lol lol , the daily average intraocular pressure was lower ( MD - 1.84 mmol - 3.34 , - 0.34 mmol , P = 0.02 ) when the two drugs were used at night . The daily average intraocular pressure was higher ( MD0 . 78 卤 0.50 , 1.06 渭m , P 0 . 00001 ) than that of the fixed combination of 0.03 % bimatroprost and0.5 % thilol ( MD0 . 78 卤 0 . 50 , 1.06 渭m , P 0 . 00001 ) .
Conclusion : For patients with POAG and OHT , the control of daily average intraocular pressure and intraocular pressure fluctuation is not as good as FCBiT , and the control of daily average intraocular pressure is better than that of Fctt . A high quality randomized controlled study is required to confirm the average intraocular pressure as compared with Fctt , FCBiT , and the average intraocular pressure in 24 hours .
Objective : To compare and evaluate the IOP lowering effect in patients with POAG and OHT in patients with POAG and OHT .
Methods : CENTRAL , EMBASE , and SCI were retrieved . The control group was used as other types of fixatives . The subjects were either POAG or OHT patients randomized controlled trial or crossover trial , and MD was used as outcome measure .
Results : A total of nine clinical trials were in compliance with the criteria and included 732 subjects in the test subjects . The results were better ( MD - 0.59 , - 0.91 , - 0.26 , P = 0.0004 ) than the 2 % dozonamine / 0.5 % tiotropium bromide fixation mixture . There was no significant difference in the control of IOP fluctuations ( MD - 0.25 mmol - 0.98 , 0.47 P P = 0.49 ) o FTs vs . 0.2 % brimonnidine / 0.5 % thiatelol fixed mixture ( Fcbt , the fixed combination of 0.2 % brizol and0.5 % lol lol ) decreased daily average intraocular pressure ( MD - 0.50 , - 2.07 , 1.07 , P = 0.53 ) .
Conclusion : For patients with POAG and OHT , the effect of the daily average IOP reduction was better than that of FTs in patients with POAG and OHT . There was no significant difference in the ocular pressure fluctuation between FTs and FCD . There was no significant difference in the daily average IOP between the FTs and FCB.However , high - quality randomized controlled intraocular pressure was still needed to further confirm their effects on daily average intraocular pressure and 24 - hour intraocular pressure .
【学位授予单位】：华中科技大学
【学位级别】：博士
【学位授予年份】：2014
【分类号】：R775.2
[Abstract]:Objective : To compare and evaluate the IOP - lowering effect in patients with POAG and OHT in patients with POAG and OHT .
Methods : The subjects were randomly controlled trial or cross test of POAG or OHT , and MD was used as the outcome measure .
Results : The average intraocular pressure ( MD - 2.95 % - 3.34 , - 2.56 mmol , P0.001 ) and 24 - hour mean intraocular pressure ( MD - 2.84 - 3.57 , - 2.12 , P - 0.001 ) could be more effective than that of tiotropium . but also can reduce the fluctuation of intraocular pressure ( MD - 0.85 - 1.18 , - 0.53 billion , P0.001 ) .
Conclusion : The results showed that patients with POAG and OHT decreased the daily average intraocular pressure and the average intraocular pressure in 24 hours , and decreased the fluctuation of intraocular pressure .
Objective : To compare and evaluate the IOP lowering effect in patients with POAG and OHT in patients with POAG and OHT .
Methods : CENTRAL , EMBASE , and SCI were retrieved . The control group was used as prostaglandin - like pressure - lowering drugs . The subjects were either POAG or OHT patients randomized controlled trial or crossover trial , and MD was used as the outcome measure .
Results : There were 12 clinical trials in compliance with the criteria and included 2534 subjects in the test subjects . The daily average intraocular pressure ( MD - 1.13 , - 1 . 47 , - 0.79 diopter , P0.001 ) and 24 - hour mean intraocular pressure ( MD - 2.50 - 3.58 , - 1.42 ug , P0.001 ) were more effective than that of latanoprost . Also , IOP fluctuations ( MD - 0.65 - 1.02 , - 0.27 sqm , P = 0.0007 ) can be reduced . There was no significant difference in the mean ocular pressure ( MD0.05 ~ - 0.19 , 0.29 mmol , P = 0.68 ) than that of TPV . There was no significant difference in mean intraocular pressure ( MD0.20 - 0.44 , 0.85 mmol , P = 0.53 ) compared with the 24 - hour mean IOP reduction compared with BU.S . prost .
Conclusion : The results showed that patients with POAG and OHT had better effects on average intraocular pressure and IOP after 24 hours than that of latanoprost . The results showed that the effect of IOP was not significantly different .
Objective : To compare and evaluate the effect of combined therapy with the combination of the components in the patients with POAG and OHT .
Methods : CENTRAL , EMBASE , and SCI were retrieved . The control group was used in combination with 0.005 % latanoprost and 0.5 % thiadiazole lol . The subjects were either POAG or OHT patients randomized controlled trial or crossover trial , and MD was used as the outcome measure .
Results : Three clinical trials met the criteria and were included in 961 subjects . The average intraocular pressure was higher than that of its components ( MD1 . 10 卤 0.81 , 1 . 39 渭g , P 0 . 00001 ) . The mean intraocular pressure was not significantly different ( MD0.42 卤 0.06 , 0.89 掳 , P = 0.09 ) .
Conclusion : For patients with POAG and OHT , the effect of decreasing daily average intraocular pressure is less than that of the combined application of the components in the patients with POAG and OHT .
Objective : To compare and evaluate the IOP - lowering effect of the fixed mixture of FCLs and other prostaglandin and thiadiazole in patients with POAG and OHT .
Methods : CENTRAL , EMBASE , and SCI were retrieved . The control group was used as the fixed mixture of other prostaglandin and thiadiazole , and the subjects were either POAG or OHT patients randomized controlled trial or crossover trial , and MD was used as the outcome measure .
Results : A total of 5 clinical trials met the criteria and were included in the 720 human subjects of the test subjects . Compared with the fixed combination of 0.004 % travoprost and0.5 % lol lol , the daily average intraocular pressure was lower ( MD - 1.84 mmol - 3.34 , - 0.34 mmol , P = 0.02 ) when the two drugs were used at night . The daily average intraocular pressure was higher ( MD0 . 78 卤 0.50 , 1.06 渭m , P 0 . 00001 ) than that of the fixed combination of 0.03 % bimatroprost and0.5 % thilol ( MD0 . 78 卤 0 . 50 , 1.06 渭m , P 0 . 00001 ) .
Conclusion : For patients with POAG and OHT , the control of daily average intraocular pressure and intraocular pressure fluctuation is not as good as FCBiT , and the control of daily average intraocular pressure is better than that of Fctt . A high quality randomized controlled study is required to confirm the average intraocular pressure as compared with Fctt , FCBiT , and the average intraocular pressure in 24 hours .
Objective : To compare and evaluate the IOP lowering effect in patients with POAG and OHT in patients with POAG and OHT .
Methods : CENTRAL , EMBASE , and SCI were retrieved . The control group was used as other types of fixatives . The subjects were either POAG or OHT patients randomized controlled trial or crossover trial , and MD was used as outcome measure .
Results : A total of nine clinical trials were in compliance with the criteria and included 732 subjects in the test subjects . The results were better ( MD - 0.59 , - 0.91 , - 0.26 , P = 0.0004 ) than the 2 % dozonamine / 0.5 % tiotropium bromide fixation mixture . There was no significant difference in the control of IOP fluctuations ( MD - 0.25 mmol - 0.98 , 0.47 P P = 0.49 ) o FTs vs . 0.2 % brimonnidine / 0.5 % thiatelol fixed mixture ( Fcbt , the fixed combination of 0.2 % brizol and0.5 % lol lol ) decreased daily average intraocular pressure ( MD - 0.50 , - 2.07 , 1.07 , P = 0.53 ) .
Conclusion : For patients with POAG and OHT , the effect of the daily average IOP reduction was better than that of FTs in patients with POAG and OHT . There was no significant difference in the ocular pressure fluctuation between FTs and FCD . There was no significant difference in the daily average IOP between the FTs and FCB.However , high - quality randomized controlled intraocular pressure was still needed to further confirm their effects on daily average intraocular pressure and 24 - hour intraocular pressure .
【学位授予单位】：华中科技大学
【学位级别】：博士
【学位授予年份】：2014
【分类号】：R775.2
【共引文献】
相关期刊论文 前10条
1 William C Stewart;Jeanette A Stewart;Marko A Mychaskiw;;拉坦、曲伏及比马前列素治疗青光眼的成本效用分析(英文)[J];国际眼科杂志;2009年05期
2 赵军梅;;固定联合制剂拉坦前列素/噻吗洛尔早晨与晚间应用的比较[J];国际眼科杂志;2011年07期
3 李平余,卢清君;青光眼药物治疗的新趋势—合理联合用药[J];国外医学(眼科学分册);2004年01期
4 Haydar Erdogan;Ayse Vural Ozec;Cengiz Caner;Mustafa Ilker Toker;Mustafa Kemal Arici;Aysen Topalkara;;Effect of latanoprost/timolol and dorzolamide/tiomolol on intraocular pressure after phacoemulsification surgery[J];International Journal of Ophthalmology(English Edition);2011年02期
5 王婷;梁涛;喻文倩;刘珂凤;;拉坦噻吗滴眼液对玻璃体切割术后难治性青光眼的短期疗效[J];国际眼科杂志;2013年09期
6 Achyut N Pandey;S Sujata;;Study of long term structural and functional changes in medically controlled glaucoma[J];International Journal of Ophthalmology(English Edition);2014年01期
7 Curt Hartleben-Matkin;Diddier Prada;Rafael Mancilla-Vences;;A 4-year retrospective study of add-on therapy to the fixed combination of dorzolamide/timolol for the treatment of POAG[J];International Journal of Ophthalmology(English Edition);2014年02期
8 Murat Atabey Ozer;Mutlu Acar;Cem Yildirim;;Intraocular pressure-lowering effects of commonly used fixed combination drugs with timolol in the management of primary open angle glaucoma[J];International Journal of Ophthalmology;2014年05期
9 Yi Xing;Fa-Gang Jiang;Teng Li;;Fixed combination of latanoprost and timolol vs the individual components for primary open angle glaucoma and ocular hypertension:a systematic review and meta-analysis[J];International Journal of Ophthalmology;2014年05期
10 刘晓阳;王以朋;于斌;;后外侧融合与后路椎体间融合治疗腰椎滑脱的Meta分析[J];中国骨与关节杂志;2013年10期
相关博士学位论文 前7条
1 张震洪;他汀类药物对尿蛋白、肾脏事件、非透析患者全因死亡的系统评价[D];南方医科大学;2014年
2 何国超;接骨板vs髓内钉和髓内钉vs外固定架固定治疗成人胫骨干骨折的系统评价[D];南方医科大学;2014年
3 朱研;口服ω-3不饱和必须脂肪酸对青光眼治疗后干眼的疗效观察[D];武汉大学;2013年
4 朱y，
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