变应性鼻炎患者嗅球体积与嗅沟深度的研究

发布时间：2018-07-26 08:36

【摘要】：目的:探讨变应性鼻炎(AR)患者嗅觉功能的变化及嗅球体积、嗅沟深度与嗅觉功能的相关性。方法:选取AR患者(AR组)及无嗅觉减退的健康受试者(对照组)各100例,应用TT嗅觉测试法检查所有受试者的嗅觉功能,并行嗅球体积、嗅沟深度的MRI检查。经保守治疗1年后AR组行TT嗅觉检查及MRI嗅球体积及嗅沟深度检查,并与初次检查结果进行比较。结果:AR组左右两侧嗅球体积[分别为(29.53±3.95)mm3、(29.67±4.21)mm3]及平均嗅球体积[(29.61±4.05)mm3]均明显小于对照组[分别为(48.93±6.73)mm3、(48.81±7.43)mm3、(48.85±7.11)mm3],差异有统计学意义(t值分别为6.321、6.141、6.221,均P0.01)。AR组与对照组左右两侧嗅沟深度及平均嗅沟深度差异无统计学意义(t值分别为1.032、0.972、0.991,均P0.05)。AR组嗅觉识别阈与嗅球体积呈负相关(r=-0.46,P0.05),与嗅沟深度无关(r=-0.012,P0.05)。经保守治疗1个月,1年后复查AR组43例嗅觉功能出现不同程度恢复,但差异无统计学意义(Z=1.911,P0.05);左右两侧及平均嗅球体积相应增大,但与1年前比较,差异无统计学意义(t值分别为0.811、0.843、0.826,均P0.05)。结论:AR患者嗅觉功能减退,其嗅球体积减小,嗅沟深度不变;嗅觉功能与嗅球体积具有相关性,与嗅沟深度无关。保守治疗对AR患者嗅觉功能的恢复有一定的临床意义。
[Abstract]:Objective: to investigate the changes of olfactory function and the correlation between olfactory bulb volume olfactory groove depth and olfactory function in patients with allergic rhinitis (AR). Methods: 100 AR patients (AR group) and 100 healthy subjects without olfactory loss (control group) were selected. The olfactory function of all subjects was examined by TT olfactory test. The volume of olfactory bulb and the depth of olfactory groove were examined by MRI. After one year of conservative treatment, the AR group was examined with TT olfactory examination, MRI olfactory bulb volume and olfactory groove depth, and compared with the initial examination. Results the volume of olfactory bulb [(29.53 卤3.95) mm ~ 3, (29.67 卤4.21) mm3] and the mean volume of olfactory bulb [(29.61 卤4.05) mm3] were significantly lower in the group than in the control group [(48.93 卤6.73) mm, (48.81 卤7.43) mm, (48.85 卤7.11) mm3, respectively] (t = 6.321 卤6.1416.221, all P0.01). There was no significant difference in olfactory sulcus depth (t = 1.032 卤0.972ng0.991respectively, P0.05). The olfactory recognition threshold in AR group was negatively correlated with olfactory bulb volume (r-0.46p0.05), but not with olfactory sulcus depth (r-0.012p0.05). After 1 month of conservative treatment, 43 cases of AR group showed different degree of recovery of olfactory function, but the difference was not statistically significant (P 0.05), the volume of left and right sides and average olfactory bulb increased correspondingly, but compared with one year ago, the volume of olfactory bulb increased. The difference was not statistically significant (t = 0.811, 0.843, P < 0.05). Conclusion the volume of olfactory bulb is decreased and the depth of olfactory sulcus is unchanged in the patients with 10% AR, and the function of olfactory is correlated with the volume of olfactory bulb, but not with the depth of olfactory groove. Conservative treatment has certain clinical significance for the recovery of olfactory function in AR patients.
【作者单位】：天津医科大学研究生院;天津市环湖医院耳鼻咽喉头颈外科;
【基金】：天津市卫生局科技基金项目(No:09ky18)
【分类号】：R765.21

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