慢性迁延性中心性浆液性脉络膜视网膜病变的两种自发荧光特征

发布时间：2018-10-08 17:29

【摘要】：目的对脂褐素相关自发荧光(lipofuscin-related fundus autofluorescence,FAF)和黑色素相关近红外自发荧光(melaninrelated near-infrard fundus autofluorescence,NIA)在慢性迁延性中心性浆液性脉络膜视网膜病变(central serous chorioretinopathy,CSC)中的特征进行分析。方法回顾性分析慢性迁延性CSC患者57例63眼的临床资料,对经德国海德堡共焦激光扫描眼底血管造影仪检查的FAF、NIA和荧光素眼底血管造影(fundus fluorescence angiography,FFA)图像进行对比分析。结果 63眼中,FAF异常荧光者47眼(占74.6%),包括弱荧光39眼(占83.0%)、强荧光3眼(占6.4%)、不典型荧光5眼(占10.6%);NIA异常荧光者59眼(占93.7%),包括弱荧光48眼(占81.4%)、斑驳状荧光5眼(占8.5%)、不典型荧光6眼(占10.2%)。63眼神经上皮脱离区自发荧光表现:FAF呈异常荧光者50眼(占79.4%),包括弱荧光15眼(占30.0%)、强荧光35眼(占70.0%);NIA异常荧光57眼(占90.5%),包括颗粒样混杂荧光51眼(占89.5%)、弱荧光6眼(占10.5%)。另外,FAF和NIA显示视网膜神经脱离区病变范围大于FFA者分别有23眼和33眼,分别占36.5%和52.4%。FFA和FAF显示正常的区域而NIA表现异常者3眼,占4.8%。结论 NIA联合FAF适合于观察慢性迁延性CSC视网膜色素上皮的变化。
[Abstract]:Objective to analyze the characteristics of lipofuscin associated autofluorescence (lipofuscin-related fundus autofluorescence,FAF) and melanin-associated near infrared autofluorescence (melaninrelated near-infrard fundus autofluorescence,NIA) in chronic persistent central serous chorioretinopathy (central serous chorioretinopathy,CSC). Methods the clinical data of 57 patients with chronic persistent CSC (63 eyes) were retrospectively analyzed. The FAF,NIA and fluorescein fundus angiography (fundus fluorescence angiography,FFA) images examined by Heidelberg confocal laser scanning angiography instrument in Germany were compared and analyzed. Results in 63 eyes, 47 eyes (74.6%) had abnormal fluorescence of FFAF, including 39 eyes (83.0%) with weak fluorescence, 3 eyes (6.4%) with strong fluorescence, 59 eyes (93.7%) with abnormal fluorescence of NIA, including 48 eyes (81.4%) with weak fluorescence, 5 eyes (10.6%) with atypical fluorescence, and 81.4% with mottled fluorescence. 5 eyes (8.5%), 6 eyes (10.2%) with atypical fluorescence. 50 eyes (79.4%) of 63 eyes showed abnormal fluorescence in the neuroepithelial detachment region, including 15 eyes (30.0%) with weak fluorescence, 57 eyes (90.5%) with strong fluorescence and 35 eyes (70.0%) with abnormal fluorescence of NIA. Granular hybrid fluorescence was found in 51 eyes (89. 5%) and weak fluorescence in 6 eyes (10. 5%). In addition, 23 eyes (36.5%) and 3 eyes (4.8%) showed abnormal NIA findings in 23 eyes (36.5%) and 52.4%.FFA and FAF (3 eyes) with abnormal NIA findings in 23 eyes (36.5%) and in 33 eyes (36.5%), respectively, in which the extent of lesion in retinal detachment area was larger than that in FFA by NIA and FFAF, respectively. Conclusion NIA combined with FAF is suitable for observing the changes of retinal pigment epithelium in chronic persistent CSC.
【作者单位】：河南省立眼科医院;河南省眼科研究所;
【基金】：国家自然科学基金资助(编号:81100650)~~
【分类号】：R774.1

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