儿童疱疹性咽峡炎急性期心肌损害的实验观察
发布时间：2018-10-25 20:00
【摘要】：目的探讨柯萨奇病毒感染所致疱疹性咽峡炎患儿的心肌酶谱、心电图改变以及临床意义。 方法以2010年5月到10月,我院收治的疱疹性咽峡炎患儿,在发病时和病程3-4周均采用酶联免疫法进行柯萨奇病毒IgG抗体检测,发病时柯萨奇病毒工gG抗体阳性,病程3-4周柯萨奇病毒工gG抗体滴度升高4倍或以上的30例为观察组,以到我院查体的健康儿童30例为对照组。疱疹性咽峡炎患儿入院时常规行心肌酶谱及心电图检查。 结果观察组心肌酶谱结果均高于对照组,其中肌酸激酶(CK)163±87.63；肌酸激酶同工酶(CK-MB)33.7±22.29,与对照组肌酸激酶(CK)151.37±54.75；肌酸激酶同工酶(CK-MB)17.73±4.89比较有统计学意义, (P0.01),心肌酶谱异常率高于对照组,与对照组比较(P0.01)有统计学意义。 结论柯萨奇病毒IgG抗体滴度升高4倍或以上结合临床表现可诊断疱疹性咽峡炎,部分疱疹性咽峡炎患儿可存在并发症—心肌损害,应该引起广大临床医师的重视。
[Abstract]:Objective to investigate the myocardial enzyme spectrum, electrocardiogram (ECG) and clinical significance in children with herpetic isthmus caused by Coxsackie virus (Coxsackie virus) infection. Methods Coxsackie virus IgG antibody was detected by enzyme-linked immunosorbent assay (Elisa) in children with herpes isthmus from May to October 2010. Coxsackie virus gG antibody was positive at the time of onset. 30 cases of Coxsackie virus (Coxsackie virus) antibody titer increased 4 times or more at 3-4 weeks as observation group and 30 healthy children in our hospital as control group. Myocardial enzyme spectrum and electrocardiogram (ECG) were routinely examined on admission in children with herpes pharyngitis. Results the results of myocardial enzyme spectrum in the observation group were higher than those in the control group, including creatine kinase (CK) 163 卤87.63, creatine kinase isoenzyme (CK-MB) 33.7 卤22.29, and creatine kinase (CK) 151.37 卤54.75 in the control group. There was significant difference in creatine kinase isoenzyme (CK-MB) 17.73 卤4.89, (P0.01), the abnormal rate of myocardial enzyme spectrum was higher than that of the control group, and had statistical significance compared with the control group (P0.01). Conclusion Coxsackie virus IgG antibody titer increase by 4 times or more combined with clinical manifestations can be used to diagnose herpes isthmus. Some children with herpes isthmus may have complications-myocardial damage which should be paid more attention by clinicians.
【学位授予单位】：青岛大学
【学位级别】：硕士
【学位授予年份】：2011
【分类号】：R766.1
[Abstract]:Objective to investigate the myocardial enzyme spectrum, electrocardiogram (ECG) and clinical significance in children with herpetic isthmus caused by Coxsackie virus (Coxsackie virus) infection. Methods Coxsackie virus IgG antibody was detected by enzyme-linked immunosorbent assay (Elisa) in children with herpes isthmus from May to October 2010. Coxsackie virus gG antibody was positive at the time of onset. 30 cases of Coxsackie virus (Coxsackie virus) antibody titer increased 4 times or more at 3-4 weeks as observation group and 30 healthy children in our hospital as control group. Myocardial enzyme spectrum and electrocardiogram (ECG) were routinely examined on admission in children with herpes pharyngitis. Results the results of myocardial enzyme spectrum in the observation group were higher than those in the control group, including creatine kinase (CK) 163 卤87.63, creatine kinase isoenzyme (CK-MB) 33.7 卤22.29, and creatine kinase (CK) 151.37 卤54.75 in the control group. There was significant difference in creatine kinase isoenzyme (CK-MB) 17.73 卤4.89, (P0.01), the abnormal rate of myocardial enzyme spectrum was higher than that of the control group, and had statistical significance compared with the control group (P0.01). Conclusion Coxsackie virus IgG antibody titer increase by 4 times or more combined with clinical manifestations can be used to diagnose herpes isthmus. Some children with herpes isthmus may have complications-myocardial damage which should be paid more attention by clinicians.
【学位授予单位】：青岛大学
【学位级别】：硕士
【学位授予年份】：2011
【分类号】：R766.1
【参考文献】
相关期刊论文 前7条
1 凌伟,沈茜,王靖,徐玉莲,许育;免疫-PCR法检测柯萨奇病毒B组抗原的实验研究[J];第二军医大学学报;2001年03期
2 揣侠,陆春雨;柯萨奇病毒性心肌炎的研究进展[J];河北医科大学学报;2004年02期
3 洪建国;李臻;曹兰芳;陈培丽;王立波;鲍一笑;顾洪亮;;利巴韦林气雾剂治疗小儿上呼吸道病毒性感染的多中心临床观察[J];临床儿科杂志;2006年06期
4 文海斌,陈晖;监测危重患儿CPK的临床意义[J];实用儿科临床杂志;1997年01期
5 赵红艳,张t，
本文编号：2294686
本文链接：https://www.wllwen.com/yixuelunwen/yank/2294686.html
最近更新
教材专著
