制备方法及处方优化对复乳稳定性的影响研究

发布时间：2018-02-06 03:02

本文关键词： 复乳稳定性制备方法处方　出处：《中国药房》2017年22期 　论文类型：期刊论文

【摘要】：目的:为进一步提高复乳稳定性提供参考。方法:以"复乳""稳定性""制备方法""处方""Multiple emulsion""Stability""Preparation method""Formulation"等为关键词,组合查询1996-2016年在Pub Med、Elsevier、中国知网、万方、维普等数据库的相关文献,对复乳的制备方法和处方的优化进行综述。结果与结论:共检索到相关文献237篇,其中有效文献36篇。稳定性始终是限制复乳应用的最大因素。无论是通过一步乳化法、两步乳化法还是膜乳化法,或是加入稳定剂、调节渗透压、优化处方成分与比例等均不能使复乳足够稳定。选择合适的制备方法,优化处方的组成在增加复乳的稳定性上已取得一定的成果,但仍不能满足应用需求。针对此,自乳化复乳是一个非常有前景的研究方向。
[Abstract]:Objective: to improve the stability of the multiple emulsion for reference. Methods: "double emulsion" and "stability" and "preparation method" and "prescription" and "Multiple emulsion" "Stability" "Preparation" "method" "Formulation" as key words, query 1996-2016 years at Pub Med, Elsevier, China CNKI, Wanfang, relevant the VIP database, carries on the summary to the optimization of preparation method and prescription for double emulsion. Results and conclusion: totally 237 literatures, including 36 effective literatures. The stability is always the biggest factor limiting emulsionm application. Whether through one step emulsification method, two step emulsification method or membrane emulsification method, or adding stabilizer, osmotic adjustment, optimize the prescription composition and proportion could not make the emulsion stable enough. Choose suitable methods of preparation, composition optimization prescription has achieved certain results in increased stability of the multiple emulsion, but still not meeting For this purpose, self emulsification is a very promising research direction.

【作者单位】：广东药科大学药学院;广东药科大学中药学院;
【分类号】：R943

【参考文献】