低剂量甲氨蝶呤的抗炎作用机制及其在脊髓损伤中应用

发布时间：2018-02-06 05:50

本文关键词： 甲氨蝶呤低剂量脊髓损伤抗炎作用 JAK/STAT通路氧化反应腺苷　出处：《中国药理学通报》2017年03期 　论文类型：期刊论文

【摘要】：甲氨蝶呤具有抗炎和免疫抑制双重功效,其药理机制复杂、多样且相互协同。该文总结了低剂量甲氨蝶呤的主要抗炎机制,包括对JAK/STAT通路和炎症反应细胞核因子的抑制作用、增加腺苷的累积及细胞内甲氨蝶呤代谢产物(多聚谷氨酸化甲氨蝶呤)的作用等。此外,低剂量甲氨蝶呤可以通过降低脂质过氧化物水平、抑制氧化反应,抑制继发性脊髓损伤的炎症反应,减轻脊髓缺血/再灌注损伤和神经性疼痛等一系列药理机制发挥神经保护作用。作者就低剂量甲氨蝶呤的抗炎作用机制及其在脊髓损伤中的应用进行综述,旨在指导对甲氨蝶呤抗炎功效的进一步研究,为脊髓损伤的临床治疗寻找新型药物提供理论依据。
[Abstract]:Methotrexate has both anti-inflammatory and immunosuppressive effects, and its pharmacological mechanisms are complex, diverse and synergistic. The main anti-inflammatory mechanisms of low-dose methotrexate are summarized in this paper. These include inhibiting the JAK/STAT pathway and inflammatory nuclear factors, increasing the accumulation of adenosine and intracellular methotrexate metabolites (polyglutamic acid methotrexate), and so on. Low dose methotrexate can inhibit the inflammation of secondary spinal cord injury by reducing the level of lipid peroxide, inhibiting the oxidation reaction. A series of pharmacological mechanisms such as relieving spinal cord ischemia / reperfusion injury and neuropathic pain play a neuroprotective role. The authors review the anti-inflammatory mechanism of low dose methotrexate and its application in spinal cord injury. To guide the further study on the anti-inflammatory effect of methotrexate and to provide theoretical basis for the clinical treatment of spinal cord injury.
【作者单位】：江西科技师范大学药学院;江西中医药大学附属医院创伤骨科;
【基金】：国家自然科学基金资助项目(No 30960448) 江西省自然科学基金资助项目(No 20142BAB205023) 江西省教育厅科学技术研究项目(No GJJ14603) 江西科技师范大学第十届本科生科研基金项目
【分类号】：R96

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