阿奇霉素粉-液双室袋与传统粉针配制的比较研究

发布时间：2018-02-13 16:35

本文关键词： 阿奇霉素粉-液双室袋传统粉针　出处：《中国抗生素杂志》2017年08期 　论文类型：期刊论文

【摘要】：目的通过实验系统评价新型阿奇霉素粉-液双室袋的便利性,安全性和准确性。方法采用计算配制时间来评价双室袋的便利性;通过对配制过程中出现的刺伤、划伤等伤害人次,和配制后不溶性微粒数来评价双室袋的安全性;通过高效液相色谱法检测配制浓度和残留量来评价双室袋配制的准确性。结果双室袋配制时间明显少于粉针配制时间[(22.5±4.7)s vs(89.2±15.5)s,P0.05];配制过程中不会造成人员伤害,配制后的不溶性微粒数明显少于粉针配制(P0.05);由于双室袋配制过程中不产生药物残留,故其药物浓度更接近理论值。结论新型阿奇霉素粉-液双室袋在便利性、安全性和准确性上都明显优于粉针配制,具有显著的临床应用优势。
[Abstract]:Objective to evaluate the convenience, safety and accuracy of a new type of azithromycin powder / liquid double compartment bag. The safety of double compartment bag was evaluated by scratch injury and the number of insoluble particles after preparation. The accuracy of double chamber bag preparation was evaluated by high performance liquid chromatography (HPLC). Results the preparation time of double chamber bag was significantly shorter than that of powder needle preparation [22. 5 卤4. 7 s vs(89.2 卤15. 5 vs(89.2 P 0. 05]. The number of insoluble particles after preparation was obviously less than that of P0.05 prepared by powder needle, and the drug concentration was closer to the theoretical value because there was no drug residue in the preparation of two-compartment bag. Conclusion A new type of azithromycin powder / liquid dual-compartment bag is convenient. Safety and accuracy are obviously superior to the preparation of powder needle, has a significant advantage in clinical application.
【作者单位】：第三军医大学大坪医院野战外科研究所第一研究室创伤烧伤与复合伤国家重点实验室;
【分类号】：R927.1

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