辐射影响药物代谢的研究进展

发布时间：2018-03-01 20:16

本文关键词： 辐射药物代谢动力学药物代谢酶药物转运体　出处：《药学学报》2017年06期 　论文类型：期刊论文

【摘要】：辐射为继水、大气、噪音污染之后的第四大污染,严重危害人体健康。辐射主要来自医用射线、工业用射线、核废物和大气紫外线等,其存在的广泛性引起人们对辐射损伤效应及其机制的广泛关注。辐射分为电离辐射和非电离辐射,研究来自于环境或临床治疗的电离及非电离辐射对药物代谢的影响,对于了解辐射条件下药物在机体内的代谢和消除快慢,并指导临床合理用药具有重要意义。本文综述了电离辐射(γ-射线、X-射线、铀辐射和铯辐射)和非电离辐射(紫外线)对药物代谢的影响,阐述了辐射条件下药物代谢酶、药物转运体和药物动力学特征的变化,并探讨了其在临床上的重要意义。
[Abstract]:Radiation is the 4th major pollution following water, atmosphere and noise pollution, which seriously endangers human health. Radiation mainly comes from medical radiation, industrial radiation, nuclear waste and atmospheric ultraviolet radiation, etc. Its existence has caused widespread attention to the effects of radiation damage and its mechanisms. Radiation is classified as ionizing radiation and non-ionizing radiation, and studies the effects of ionizing and non-ionizing radiation from environmental or clinical treatments on drug metabolism, It is of great significance to understand the metabolism and elimination of drugs in the body under radiation conditions and to guide the rational use of drugs in clinic. This paper reviews the ionizing radiation (纬-ray X-ray). The effects of uranium radiation and cesium radiation) and non-ionizing radiation (UV) on drug metabolism were discussed. The changes of drug metabolic enzymes, drug transporters and pharmacokinetic characteristics under radiation conditions were discussed, and their clinical significance was discussed.
【作者单位】：青海大学医学院;青海大学生态环境工程学院;青海大学三江源生态与高原农牧业国家重点实验室;
【基金】：国家自然科学基金资助项目(81460568) 教育部新世纪优秀人才支持计划资助项目(NCET-10-0917) 青海省自然科学基金资助项目(2016-ZJ-902)
【分类号】：R96

【相似文献】