新型抗耐药革兰阳性菌药物研究进展

发布时间：2018-03-18 20:35

本文选题：耐药　切入点：革兰阳性菌　出处：《中国药房》2015年01期 　论文类型：期刊论文

【摘要】：目的:综述各类新型抗耐药革兰阳性(G+)菌药物或候选物的研究进展。方法:以"新型抗菌药物""抗耐药G+菌""Novel antimicrobial agents""Multi-drug-resistant""Gram-positive"等为关键词,组合查询2005年1月至2014年2月维普中文检索数据库、Pub Med中有关新型抗耐药G+菌药物的研究文献,对各类新型抗耐药G+菌药物或候选物的研究资料进行汇总分析。结果:共查阅到90余条文献,得到有效文献47条。目前,各类新型抗耐药G+菌药物研发方向较多,主要包括新型糖肽类、新型头孢菌素类、新型碳青霉烯类、新型大环内酯类、四环素类、链阳霉素、新型唑烷酮类、脂肪酸合成酶抑制剂等。结论:目前出现了多种具有广阔临床应用前景的新型抗耐药G+菌药物或候选物,特别是特拉万星、达巴万星、奥利万星、头孢吡普、头孢洛林、喹红霉素、雷得唑来、泰地唑利、阿祖培南、托莫培南等,为耐甲氧西林金黄色葡萄球菌、耐万古霉素肠球菌等耐药G+菌株的治疗带来了新希望。
[Abstract]:Objective: to review the research progress of novel drugs or candidates of Gram-positive G) bacteria. Methods: "New antimicrobial agents", "resistant G bacteria", "Novel antimicrobial agents", "Multi-drug-resistant" and "Gram-positive" were used as keywords. From January 2005 to February 2014, the Chinese search database of Pub Med was used to search the literature on novel drug resistant G bacteria. Results: more than 90 literatures were reviewed and 47 effective documents were obtained. At present, there are many research directions of new drug resistant G bacteria drugs. It mainly includes new glycopeptides, new cephalosporins, new carbapenems, new macrolides, tetracyclines, streptomycin, new azolones, Conclusion: there are many novel drugs or candidates for drug resistance G bacteria with broad clinical application prospects, especially Travacin, Dabavan, Oryvanine, cefepiripine, Cefalopramide, Cefalopramide, Cefalopril, Cefalopril, Cefalopril, Cefolorin, and so on. Quinrithromycin, Redzolae, Tidazolil, Azupenem, Tomopenem, etc., which bring new hope for the treatment of methicillin-resistant Staphylococcus aureus and vancomycin resistant Enterococcus.
【作者单位】：山东省文登整骨医院;
【分类号】：R978.1

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