霉酚酸钠肠溶片用于国人肾移植受者的药代动力学监测

发布时间：2018-03-23 09:05

本文选题：肾移植　切入点：霉酚酸　出处：《山东医药》2015年18期 　论文类型：期刊论文

【摘要】：目的观察服用霉酚酸钠肠溶片(EC-MPS)的国人肾移植受者血中霉酚酸(MPA)的药代动力学特征,建立简化的MPA血浆浓度—时间曲线下面积(AUC)的计算公式。方法 30例肾移植受者均接受EC-MPS 1.44g/d联合环孢素、强的松的三联免疫抑制方案。采用EMIT法测服药前及服药后0.5、1、1.5、2、4、6、8、10、12 h的血浆MPA浓度(分别为C0.5、C1、C1.5、C2、C4、C6、C8、C10、C12)。采用药理学专用软件计算MPA AUC0~12 h,并以多元逐步回归分析法得出适合国人的MPA AUC0~12 h的简化计算公式。结果 30例肾移植受者EC-MPS的药代动力学参数存在显著个体差异。MPA AUC0~12 h平均值为(47.64±25.14)mg·h/L。选取2个取样时点的C1.5、C2和4个取样时点的C2、C4、C6、C8,分别得出MPA AUC的简化计算公式:AUC=27.41+0.87×C1.5+0.88×C2(r2=0.67)和AUC=3.98+2.03×C2+2.18×C4+1.91×C6+5.08×C8(r2=0.86),其对MPA AUC预测值的绝对误差分别为(28.8±24.8)%和(12.8±10.1)%;30例肾移植受者中,MPA AUC预测值误差均在MPA AUC0~12 h的±15%以内。结论服用EC-MPS的国人肾移植受者血浆中MPA药代动力学呈现较大的个体差异;得出取样点少(2个取样时点或4个取样时点)、预测效果好的MPA AUC简化计算公式。
[Abstract]:Objective to observe the pharmacokinetic characteristics of mycophenolate mofetil (MPA) in blood of Chinese renal transplant recipients taking sodium mycophenolate mofetil enteric-coated tablets (EC-MPS). A simplified formula for calculating the area under the plasma concentration-time curve of MPA was established. Methods 30 renal transplant recipients received EC-MPS 1.44g/d combined with cyclosporine. The triplex immunosuppressive regimen of prednisone. The plasma MPA concentrations before and after taking the drug were measured by EMIT method (C 0.5 C 1, C 1. 5 C 1. 5, C 2 5, C 2 5, C 4, C 4, C 6, C 6, C 8, C 10, C 12) before and after taking the drug. The MPA AUC0~12 hs were calculated by using a special pharmacology software, and the results of multivariate stepwise regression analysis were used to obtain a suitable method for Chinese people. Results the pharmacokinetic parameters of EC-MPS in 30 renal transplant recipients showed significant individual differences. The mean value of AUC0~12 h was 47.64 卤25.14)mg h / L. MPA was obtained by selecting two sampling time points C1.5 C 2 and four sampling time points C 2 C 4 C 6 C 8, respectively. The simplified formula of AUC was 27.41 0.87 脳 C1.5 0.88 脳 C2R20.67) and AUC=3.98 2.03 脳 C2 2.18 脳 C4 1.91 脳 C65.08 脳 C8R20.86. The absolute error of AUC prediction for MPA AUC was 28.8 卤24.8% and 12.8 卤10.1% respectively. The pharmacokinetics of MPA in the plasma of recipients showed great individual difference. The simplified calculation formula of MPA AUC with good prediction effect is obtained with few sampling points (2 sampling points or 4 sampling points).
【作者单位】：上海交通大学医学院附属瑞金医院;
【基金】：卫生部国际交流与合作中心2012年度器官移植科研项目(IHECC08-201212)
【分类号】：R969.1

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