维生素E醋酸酯的合成

发布时间：2018-03-23 10:29

本文选题：维生素E　切入点：维生素E醋酸酯　出处：《重庆医科大学》2014年硕士论文

【摘要】：目的：改良维生素E醋酸酯的合成工艺，降低合成的成本，提高操作的便捷性和对环境的友好度；方法：以2,3,6-三甲基苯酚为原料，在空气中氧化成2,3,5-三甲基对苯醌，，氢化还原成2,3,5-三甲基氢醌，其与异植物醇发生缩合反应，生成维生素E，再在醋酐作用下得到目标产物。结果：以廉价易得的原料和简化的工艺步骤合成了目标化合物，结构经质谱和核磁共振谱确证，反应收总率为84.5%。结论：本工艺具有工业化生产潜力。
[Abstract]:Objective: to improve the synthesis process of vitamin E acetate, reduce the cost of synthesis, improve the convenience of operation and environmental friendliness. Methods: the product was oxidized in air to form 2o 3N 5- trimethyl p-benzoquinone, and then hydrogenated to form 2o 3 N 5-trimethyl hydroquinone. The product was condensed with iso-phytol to form vitamin E, and then the target product was obtained by acetic anhydride. Results: the target compound was synthesized by cheap and easy to obtain raw material and simplified process. The structure was confirmed by mass spectrometry and nuclear magnetic resonance spectroscopy. The total yield of the reaction was 84.5%. Conclusion: this process has the potential of industrial production.
【学位授予单位】：重庆医科大学
【学位级别】：硕士
【学位授予年份】：2014
【分类号】：R914

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